Peroxisome proliferator-activated receptors: mediators of phthalate ester-induced effects in the male reproductive tract?
TLDR
Critical research needs are identified that will help determine the significance of PPARs in phthalate-induced effects in the rat male reproductive tract and the relevance of toxicity to humans.About:
This article is published in Toxicological Sciences.The article was published on 2005-01-01 and is currently open access. It has received 151 citations till now. The article focuses on the topics: Peroxisome proliferator-activated receptor & Steroid biosynthesis.read more
Citations
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A critical analysis of the biological impacts of plasticizers on wildlife.
Jörg Oehlmann,Ulrike Schulte-Oehlmann,Werner Kloas,Oana Jagnytsch,Ilka Lutz,Kresten Ole Kusk,Leah Wollenberger,Eduarda M. Santos,Gregory C. Paull,Katrien J. W. Van Look,Charles R. Tyler +10 more
TL;DR: Most plasticizers appear to act by interfering with the functioning of various hormone systems, but some phthalates have wider pathways of disruption, and given the sensitivity of some invertebrates, effects assessments are warranted in other invertebrate phyla.
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Concentrations of Urinary Phthalate Metabolites Are Associated with Increased Waist Circumference and Insulin Resistance in Adult U.S. Males
TL;DR: Investigating phthalate exposure and its associations with abdominal obesity and insulin resistance in adult U.S. men suggested that exposure to these phthalates may contribute to the population burden of obesity, insulin resistance, and related clinical disorders.
Journal ArticleDOI
Reproductive and Developmental Toxicity of Phthalates
Jan Ludvig Lyche,Arno C. Gutleb,Åke Bergman,Gunnar Sundstøl Eriksen,Albertinka J. Murk,Erik Ropstad,Margaret Saunders,Janneche Utne Skaare +7 more
TL;DR: It is concluded that it is important to improve the knowledge of toxic interactions among the different chemicals and to develop measures for combined exposure to various groups of phthalates.
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Prenatal phthalate exposure is associated with childhood behavior and executive functioning
Stephanie M. Engel,Amir Miodovnik,Richard L. Canfield,Chenbo Zhu,Manori J. Silva,Antonia M. Calafat,Mary S. Wolff +6 more
TL;DR: Behavior domains adversely associated with prenatal exposure to LMW phthalates in this study are commonly found to be affected in children clinically diagnosed with conduct or attention deficit hyperactivity disorders.
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Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction
TL;DR: Findings in human populations are consistent with animal data suggesting that PAEs and their metabolites produce toxic effects in the reproductive system, but it is not yet possible to conclude whether phthalate exposure is harmful for human reproduction.
References
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Journal ArticleDOI
Testicular dysgenesis syndrome ; an increasingly common developmental disorder with environmental aspects
TL;DR: Existing evidence supporting a new concept that poor semen quality, testis cancer, undescended testis and hypospadias are symptoms of one underlying entity, the testicular dysgenesis syndrome (TDS), which may be increasingly common due to adverse environmental influences is summarized.
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PPAR gamma is required for placental, cardiac, and adipose tissue development.
Yaacov Barak,Michael C. Nelson,Michael C. Nelson,Estelita S. Ong,Estelita S. Ong,Ying Jones,Pilar Ruiz-Lozano,Kenneth R. Chien,Alan Koder,Ronald M. Evans,Ronald M. Evans +10 more
TL;DR: Findings both confirm and expand the current known spectrum of physiological functions regulated by PPAR gamma, implicating a previously unrecognized dependence of the developing heart on a functional placenta.
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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Susanna S.T. Lee,Thierry Pineau,John Drago,Eric J. Lee,Jennie W. Owens,Deanna L. Kroetz,Pedro M. Fernández-Salguero,Heiner Westphal,Frank J. Gonzalez +8 more
TL;DR: It is demonstrated that mPPAR alpha is the major isoform required for mediating the pleiotropic response resulting from the actions of peroxisome proliferators.
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Male reproductive health and environmental xenoestrogens
Jorma Toppari,John Chr. Larsen,Peter Christiansen,Aleksander Giwercman,Philippe Grandjean,Louis J. Guillette,Bernard Jégou,Tina Kold Jensen,Pierre Jouannet,Niels Keiding,Henrik Leffers,John A. McLachlan,Otto A. Meyer,Jørn Müller,E. Rajpert-De Meyts,Thomas H. Scheike,Richard M. Sharpe,John P. Sumpter,Niels E. Skakkebæk +18 more
TL;DR: The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active environmental chemicals during fetal and childhood development.
Journal ArticleDOI
The environmental fate of phthalate esters: A literature review
TL;DR: A comprehensive and critical review of the environmental fate of eighteen commercial phthalate esters with alkyl chains ranging from 1 to 13 carbons was performed by as discussed by the authors, which revealed that most published values exceed true water solubilities due to experimental difficulties associated with solubility determinations for these hydrophobic organic liquids.