Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study.
Daouda Sissoko,Sophie Duraffour,Romy Kerber,Jacques Seraphin Kolié,Abdoul Habib Beavogui,Alseny Modet Camara,Géraldine Colin,Toni Rieger,Lisa Oestereich,Bernadett Pályi,Stephanie Wurr,Jeremie Guedj,Thi Huyen Tram Nguyen,Rosalind M Eggo,Conall H. Watson,W. John Edmunds,Joseph Akoi Bore,Fara Raymond Koundouno,Mar Cabeza-Cabrerizo,Lisa L. Carter,Liana E. Kafetzopoulou,Eeva Kuisma,Janine Michel,Livia Victoria Patrono,Natasha Y. Rickett,Katrin Singethan,Martin Rudolf,Angelika Lander,Elisa Pallasch,Sabrina Bockholt,Estefanía Rodríguez,Antonino Di Caro,Roman Wölfel,Martin Gabriel,Cèline Gurry,Pierre Formenty,Sakoba Keita,Denis Malvy,Miles W. Carroll,Miles W. Carroll,Xavier Anglaret,Stephan Günther +41 more
TLDR
Using the biostatistical model, it is predicted that 50% and 90% of male survivors clear Ebola virus RNA from seminal fluid at 115 days (90% prediction interval 72-160) and 294 days (212-399) after disease onset, respectively, and the number of men positive for Ebola virusRNA in affected countries would decrease from about 50 in January 2016, to fewer than 1 person by July, 2016.About:
This article is published in The Lancet Global Health.The article was published on 2017-01-01 and is currently open access. It has received 99 citations till now. The article focuses on the topics: Ebola virus & European union.read more
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Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report
Deen Gf,Nathalie Broutet,Wenbo Xu,Barbara Knust,F. R. Sesay,McDonald Slr,Elizabeth Ervin,Jaclyn E. Marrinan,Philippe Gaillard,N. Habib,Hui Liu,Liu W,Anna Thorson,F. Yamba,Thomas Massaquoi,James F,Archchun Ariyarajah,Christine Ross,Kyle T. Bernstein,A. Coursier,John D. Klena,M. Carino,Wurie Ah,Yong Zhang,Dumbuya Ms,Neetu Abad,Idriss B,Wi T,Sarah D. Bennett,Davies T,Ebrahim Fk,Elissa Meites,Naidoo D,Smith Sj,Ongpin P,Tasneem Malik,Banerjee A,Bobbie R. Erickson,Yanmin Liu,Ke Xu,Aaron C. Brault,Kara N. Durski,Jörn Winter,Tara K. Sealy,Stuart T. Nichol,Lamunu M,Bangura J,Landoulsi S,Jambai A,Oliver Morgan,Guizhen Wu,Liang M,Su Q,Lan Y,Hao Y,Pierre Formenty,Ute Ströher,Foday Sahr +57 more
TL;DR: These data showed the long‐term presence of Ebola virus RNA in semen and declining persistence with increasing time after ETU discharge, as well as the risk of sexual transmission of EVD.
Journal ArticleDOI
Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection.
Carl W. Davis,Katherine J. L. Jackson,Katherine J. L. Jackson,Anita K. McElroy,Anita K. McElroy,Anita K. McElroy,Peter Halfmann,Jessica Huang,Chakravarthy Chennareddy,Ashley E. Piper,Yvonne Leung,César G. Albariño,Ian Crozier,Ali H. Ellebedy,Ali H. Ellebedy,John Sidney,Alessandro Sette,Alessandro Sette,Tianwei Yu,Sandra C. A. Nielsen,Arthur J. Goff,Christina F. Spiropoulou,Erica Ollman Saphire,Erica Ollman Saphire,Guy Cavet,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Aneesh K. Mehta,Pamela J. Glass,Scott D. Boyd,Rafi Ahmed +30 more
TL;DR: This study provides a benchmark for assessing EBOV vaccine-induced immunity, with striking changes occurred in the immunoglobulin repertoire, with massive recruitment of naive B cells that subsequently underwent hypermutation.
Journal ArticleDOI
Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques.
Jeremie Guedj,Géraldine Piorkowski,Frédéric Jacquot,Vincent Madelain,Thi Huyen Tram Nguyen,Anne Rodallec,Anne Rodallec,Stephan Günther,Caroline Carbonnelle,Hervé Raoul,Xavier de Lamballerie +10 more
TL;DR: The results suggest that favipiravir may be an effective antiviral drug against Ebola virus that relies on RNA chain termination and possibly error catastrophe, and support a potential role for high doses of favipIRavir for future human interventions.
Journal ArticleDOI
COVID-19 false dichotomies and a comprehensive review of the evidence regarding public health, COVID-19 symptomatology, SARS-CoV-2 transmission, mask wearing, and reinfection.
Kevin Escandón,Angela L. Rasmussen,Angela L. Rasmussen,Isaac I. Bogoch,Eleanor J Murray,Karina Escandón,Saskia V. Popescu,Saskia V. Popescu,Jason Kindrachuk,Jason Kindrachuk +9 more
TL;DR: In this paper, the authors deconstruct six common COVID-19 false dichotomies, address the evidence on these topics, identify insights relevant to effective pandemic responses, and highlight knowledge gaps and uncertainties.
References
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Ebola Virus Disease in West Africa — The First 9 Months of the Epidemic and Forward Projections
TL;DR: This work analyzed a detailed subset of data on 3343 confirmed and 667 probable Ebola cases collected in Guinea, Liberia, Nigeria, and Sierra Leone as of September 14 to estimate the case fatality rate and the course of infection.
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Assessment of the Risk of Ebola Virus Transmission from Bodily Fluids and Fomites
Daniel G. Bausch,Daniel G. Bausch,Jonathan S. Towner,Scott F. Dowell,Felix Kaducu,Matthew Lukwiya,Anthony Sanchez,Stuart T. Nichol,Thomas G. Ksiazek,Pierre E. Rollin +9 more
TL;DR: It is concluded that EBOV is shed in a wide variety of bodily fluids during the acute period of illness but that the risk of transmission from fomites in an isolation ward and from convalescent patients is low when currently recommended infection control guidelines for the viral hemorrhagic fevers are followed.
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Maximum likelihood estimation in nonlinear mixed effects models
E. Kuhn,Marc Lavielle +1 more
TL;DR: A stochastic approximation version of EM for maximum likelihood estimation of a wide class of nonlinear mixed effects models is proposed, able to provide an estimator close to the MLE in very few iterations.
Journal ArticleDOI
Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea.
Daouda Sissoko,Cédric Laouénan,Elin Folkesson,Abdoul-Bing M’Lebing,Abdoul-Habib Beavogui,Sylvain Baize,Sylvain Baize,Alseny-Modet Camara,Piet Maes,Susan Shepherd,Christine Danel,Sara Carazo,Mamoudou N. Conde,Jean-Luc Gala,Géraldine Colin,Hélène Savini,Joseph Akoi Bore,Frédéric Le Marcis,Fara Raymond Koundouno,Frédéric Petitjean,Marie-Claire Lamah,Sandra Diederich,Alexis Tounkara,Geertrui Poelart,Emmanuel Berbain,Jean-Michel Dindart,Sophie Duraffour,Annabelle Lefevre,Tamba Leno,Olivier Peyrouset,Leonid M. Irenge,N’Famara Bangoura,Romain Palich,Julia Hinzmann,Annette Kraus,Thierno Sadou Barry,Sakoba Berette,André Bongono,Mohamed Seto Camara,Valérie Chanfreau Munoz,Lanciné Doumbouya,Souley Harouna,Patient Mumbere Kighoma,Fara Roger Koundouno,Réné Lolamou,Cécé Moriba Loua,Vincent Massala,Kinda Moumouni,Célia Provost,Nenefing Samake,Conde Sekou,Abdoulaye Soumah,Isabelle Arnould,Michel Saa Komano,Lina Gustin,Carlotta Berutto,Diarra Camara,Fodé Saydou Camara,Joliene Colpaert,Léontine Delamou,Lena Jansson,Etienne Kourouma,Maurice Loua,Kristian Nødtvedt Malme,Emma Manfrin,André Maomou,Adele Milinouno,Sien Ombelet,Aboubacar Youla Sidiboun,Isabelle Verreckt,Pauline Yombouno,Anne Bocquin,Caroline Carbonnelle,Thierry Carmoi,Pierre Frange,Stéphane Mély,Vinh-Kim Nguyen,Delphine Pannetier,Anne-Marie Taburet,Jean-Marc Treluyer,Jacques Seraphin Kolié,Raoul Moh,Minerva Cervantes Gonzalez,Eeva Kuisma,Britta Liedigk,Didier Ngabo,Martin Rudolf,Ruth Thom,Romy Kerber,Martin Gabriel,Antonino Di Caro,Roman Wölfel,Jamal Badir,Mostafa Bentahir,Yann Deccache,Catherine Dumont,Jean-François Durant,Karim El Bakkouri,Marie Gasasira Uwamahoro,Benjamin Smits,Nora Toufik,Stéphane Van Cauwenberghe,Khaled Ezzedine,Eric D'Ortenzio,Louis Pizarro,Aurélie Etienne,Jeremie Guedj,Alexandra Fizet,Alexandra Fizet,Eric Barte de Sainte Fare,Bernadette Murgue,Tuan Tran-Minh,Christophe Rapp,Pascal Piguet,Marc Poncin,Bertrand Draguez,Thierry Allaford Duverger,Solenne Barbe,Guillaume Baret,Isabelle Defourny,Miles W. Carroll,Miles W. Carroll,Hervé Raoul,Augustin Augier,Serge Eholié,Yazdan Yazdanpanah,Claire Levy-Marchal,Annick Antierrens,Michel Van Herp,Stephan Günther,Xavier de Lamballerie,Sakoba Keita,Xavier Anglaret,Denis Malvy +133 more
TL;DR: The objectives of the trial were to test the feasibility and acceptability of an emergency trial in the context of a large Ebola outbreak, and to collect data on the safety and effectiveness of favipiravir in reducing mortality and viral load in patients with EVD.
Journal ArticleDOI
Molecular Evidence of Sexual Transmission of Ebola Virus
Suzanne Mate,Jeffrey R. Kugelman,Tolbert Nyenswah,Jason T. Ladner,Michael R. Wiley,Thierry Cordier-Lassalle,Athalia Christie,Gary P. Schroth,Stephen M. Gross,Gloria Davies-Wayne,Shivam A. Shinde,Ratnesh Murugan,Sonpon B. Sieh,Moses Badio,Lawrence Fakoli,Fahn Taweh,Emmie de Wit,Neeltje van Doremalen,Vincent J. Munster,James Pettitt,Karla Prieto,Ben W. Humrighouse,Ute Ströher,Joseph W. Diclaro,Lisa E. Hensley,Randal J. Schoepp,David Safronetz,Joseph N. Fair,Jens H. Kuhn,David J. Blackley,A. Scott Laney,Desmond E. Williams,Terrence Lo,Alex Gasasira,Stuart T. Nichol,Pierre Formenty,Francis Kateh,Kevin M. De Cock,Fatorma K. Bolay,Mariano Sanchez-Lockhart,Gustavo Palacios +40 more
TL;DR: The genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission of Ebola virus disease and provided evidence of sexual transmission of EBOV and evidence of the persistence of infective E BOV in semen for 179 days or more after the onset of EVD.
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Molecular Evidence of Sexual Transmission of Ebola Virus
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Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report
Deen Gf,Nathalie Broutet,Wenbo Xu,Barbara Knust,F. R. Sesay,McDonald Slr,Elizabeth Ervin,Jaclyn E. Marrinan,Philippe Gaillard,N. Habib,Hui Liu,Liu W,Anna Thorson,F. Yamba,Thomas Massaquoi,James F,Archchun Ariyarajah,Christine Ross,Kyle T. Bernstein,A. Coursier,John D. Klena,M. Carino,Wurie Ah,Yong Zhang,Dumbuya Ms,Neetu Abad,Idriss B,Wi T,Sarah D. Bennett,Davies T,Ebrahim Fk,Elissa Meites,Naidoo D,Smith Sj,Ongpin P,Tasneem Malik,Banerjee A,Bobbie R. Erickson,Yanmin Liu,Ke Xu,Aaron C. Brault,Kara N. Durski,Jörn Winter,Tara K. Sealy,Stuart T. Nichol,Lamunu M,Bangura J,Landoulsi S,Jambai A,Oliver Morgan,Guizhen Wu,Liang M,Su Q,Lan Y,Hao Y,Pierre Formenty,Ute Ströher,Foday Sahr +57 more
Persistence and Genetic Stability of Ebola Virus during the Outbreak in Kikwit, Democratic Republic of the Congo, 1995
Luis L. Rodriguez,Luis L. Rodriguez,Luis L. Rodriguez,A. De Roo,A. De Roo,Y. Guimard,Y. Guimard,Sam G. Trappier,Sam G. Trappier,Anthony Sanchez,Anthony Sanchez,David S. Bressler,David S. Bressler,A. J. Williams,A. J. Williams,Alexander K. Rowe,Alexander K. Rowe,Jeanne Bertolli,Jeanne Bertolli,Ali S. Khan,Ali S. Khan,Thomas G. Ksiazek,Thomas G. Ksiazek,C. J. Peters,C. J. Peters,Stuart T. Nichol,Stuart T. Nichol +26 more
Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea.
Daouda Sissoko,Cédric Laouénan,Elin Folkesson,Abdoul-Bing M’Lebing,Abdoul-Habib Beavogui,Sylvain Baize,Sylvain Baize,Alseny-Modet Camara,Piet Maes,Susan Shepherd,Christine Danel,Sara Carazo,Mamoudou N. Conde,Jean-Luc Gala,Géraldine Colin,Hélène Savini,Joseph Akoi Bore,Frédéric Le Marcis,Fara Raymond Koundouno,Frédéric Petitjean,Marie-Claire Lamah,Sandra Diederich,Alexis Tounkara,Geertrui Poelart,Emmanuel Berbain,Jean-Michel Dindart,Sophie Duraffour,Annabelle Lefevre,Tamba Leno,Olivier Peyrouset,Leonid M. Irenge,N’Famara Bangoura,Romain Palich,Julia Hinzmann,Annette Kraus,Thierno Sadou Barry,Sakoba Berette,André Bongono,Mohamed Seto Camara,Valérie Chanfreau Munoz,Lanciné Doumbouya,Souley Harouna,Patient Mumbere Kighoma,Fara Roger Koundouno,Réné Lolamou,Cécé Moriba Loua,Vincent Massala,Kinda Moumouni,Célia Provost,Nenefing Samake,Conde Sekou,Abdoulaye Soumah,Isabelle Arnould,Michel Saa Komano,Lina Gustin,Carlotta Berutto,Diarra Camara,Fodé Saydou Camara,Joliene Colpaert,Léontine Delamou,Lena Jansson,Etienne Kourouma,Maurice Loua,Kristian Nødtvedt Malme,Emma Manfrin,André Maomou,Adele Milinouno,Sien Ombelet,Aboubacar Youla Sidiboun,Isabelle Verreckt,Pauline Yombouno,Anne Bocquin,Caroline Carbonnelle,Thierry Carmoi,Pierre Frange,Stéphane Mély,Vinh-Kim Nguyen,Delphine Pannetier,Anne-Marie Taburet,Jean-Marc Treluyer,Jacques Seraphin Kolié,Raoul Moh,Minerva Cervantes Gonzalez,Eeva Kuisma,Britta Liedigk,Didier Ngabo,Martin Rudolf,Ruth Thom,Romy Kerber,Martin Gabriel,Antonino Di Caro,Roman Wölfel,Jamal Badir,Mostafa Bentahir,Yann Deccache,Catherine Dumont,Jean-François Durant,Karim El Bakkouri,Marie Gasasira Uwamahoro,Benjamin Smits,Nora Toufik,Stéphane Van Cauwenberghe,Khaled Ezzedine,Eric D'Ortenzio,Louis Pizarro,Aurélie Etienne,Jeremie Guedj,Alexandra Fizet,Alexandra Fizet,Eric Barte de Sainte Fare,Bernadette Murgue,Tuan Tran-Minh,Christophe Rapp,Pascal Piguet,Marc Poncin,Bertrand Draguez,Thierry Allaford Duverger,Solenne Barbe,Guillaume Baret,Isabelle Defourny,Miles W. Carroll,Miles W. Carroll,Hervé Raoul,Augustin Augier,Serge Eholié,Yazdan Yazdanpanah,Claire Levy-Marchal,Annick Antierrens,Michel Van Herp,Stephan Günther,Xavier de Lamballerie,Sakoba Keita,Xavier Anglaret,Denis Malvy +133 more