PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors
Ching Yi Chen,Tae Hee Kim,Wen Chung Wu,Chi Ming Huang,Hua Wei,Christopher W. Mount,Yanqing Tian,Sei Hum Jang,Suzie H. Pun,Alex K.-Y. Jen +9 more
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TLDR
Doxorubicin-loaded micelles formed from a series of dual pH- and temperature-responsive block copolymers were stable at blood pH and showed increased drug release at acidic pH and displayed more potent anti-cancer activity than free doxorUBicin when tested in a tumor xenograft model in mice.About:
This article is published in Biomaterials.The article was published on 2013-06-01 and is currently open access. It has received 125 citations till now. The article focuses on the topics: Drug carrier & Micelle.read more
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Advances in Biomaterials for Drug Delivery.
TL;DR: Advances in biomaterials for drug delivery are enabling significant progress in biology and medicine, including major breakthroughs in materials for cancer immunotherapy, autoimmune diseases, and genome editing.
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Activated Ester Containing Polymers: Opportunities and Challenges for the Design of Functional Macromolecules
Anindita Das,Patrick Theato +1 more
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Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances
Mahdi Karimi,Parham Sahandi Zangabad,Parham Sahandi Zangabad,Alireza Ghasemi,Mohammad Amiri,Mohsen Bahrami,Hedieh Malekzad,Hadi Ghahramanzadeh Asl,Zahra Mahdieh,Mahnaz Bozorgomid,Amir Ghasemi,Mohammad Reza Rahmani Taji Boyuk,Michael R. Hamblin,Michael R. Hamblin +13 more
TL;DR: In this review, it is attempted to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.
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Thermo-sensitive polymers in medicine: A review
Payam Zarrintaj,Payam Zarrintaj,Maryam Jouyandeh,Mohammad Reza Ganjali,Behzad Shirkavand Hadavand,Masoud Mozafari,Sergei S. Sheiko,Mohammad Vatankhah-Varnoosfaderani,Tomy J. Gutiérrez,Mohammad Reza Saeb +9 more
TL;DR: The functional design of the TSPs, their biomedical applications and the road ahead for their developments are comprehensively overviewed.
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Self-assembled pH-responsive hyaluronic acid-g-poly((L)-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin.
Lipeng Qiu,Zhen Li,Mingxi Qiao,Miaomiao Long,Mingyue Wang,Xiaojun Zhang,Chenmin Tian,Dawei Chen,Dawei Chen +8 more
TL;DR: Results confirm that the biocompatible pH-responsive HA-PHis micelles are a promising nanosystem for the intracellular targeted delivery of DOX.
References
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Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.
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Controlled/"living" radical polymerization. atom transfer radical polymerization in the presence of transition-metal complexes
Journal Article
Blood Flow, Oxygen and Nutrient Supply, and Metabolic Microenvironment of Human Tumors: A Review
TL;DR: Current knowledge of blood flow and perfusion-related parameters, which usually go hand in hand and in turn define the cellular metabolic microenvironment of human malignancies, are summarized for predicting the acute and/or long-term response of tumors to therapy.
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Thermosensitive sol-gel reversible hydrogels.
TL;DR: It is timely to summarize the polymeric systems that undergo sol-gel transitions, particularly due to temperature, with emphasis on the underlying transition mechanisms and potential delivery aspects.