Photoacoustic microscopy: Photoacoustic microscopy
Junjie Yao,Lihong V. Wang +1 more
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TLDR
Focusing on state-of-the-art developments in PAM, this Review discusses the key features of PAM implementations and their applications in biomedical studies.Abstract:
Photoacoustic microscopy (PAM) is a hybrid in vivo imaging technique that acoustically detects optical contrast via the photoacoustic effect. Unlike pure optical microscopic techniques, PAM takes advantage of the weak acoustic scattering in tissue and thus breaks through the optical diffusion limit (~1 mm in soft tissue). With its excellent scalability, PAM can provide high-resolution images at desired maximum imaging depths up to a few millimeters. Compared with backscattering-based confocal microscopy and optical coherence tomography, PAM provides absorption contrast instead of scattering contrast. Furthermore, PAM can image more molecules, endogenous or exogenous, at their absorbing wavelengths than fluorescence-based methods, such as wide-field, confocal, and multi-photon microscopy. Most importantly, PAM can simultaneously image anatomical, functional, molecular, flow dynamic and metabolic contrasts in vivo. Focusing on state-of-the-art developments in PAM, this Review discusses the key features of PAM implementations and their applications in biomedical studies.read more
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Journal ArticleDOI
Modeling toolchain for realistic simulation of photoacoustic data acquisition
Jan-Willem Muller,M.Ü. Arabul,Hans-Martin Schwab,Marcel C. M. Rutten,Marc R.H.M. van Sambeek,Min Wu,Richard G.P. Lopata +6 more
TL;DR: A quantitative toolchain was developed to model PA image acquisition in complex tissues, by simulating both the optical fluence and the acoustic wave propagation and the results indicate a great potential of PA simulations in more complex and heterogeneous media.
Posted ContentDOI
Cardiac-Gated Spectroscopic Photoacoustic Imaging for Ablation-Induced Necrotic Lesion Visualization: In Vivo Demonstration in a Beating Heart
Shang Gao,Hiroshi Ashikaga,Masahito Suzuki,Tommaso Mansi,Young-Ho Kim,Florin C. Ghesu,Jeeun Kang,Emad M. Boctor,Henry R. Halperin,Haichong K. Zhang +9 more
TL;DR: The introduced CG-sPA imaging system has the great potential to be incorporated into clinical workflow to guide ablation procedures intraoperatively and introduced a framework for mapping the necrotic lesion based on cardiac-gated sPA imaging.
Journal ArticleDOI
Hessian filter-assisted full diameter at half maximum (FDHM) segmentation and quantification method for optical-resolution photoacoustic microscopy.
Dong Zhang,Ran Li,Maomao Chen,Xin Lou,Jianwen Luo Department of Biomedical Engineering,School of Clinical Medicine,Tsinghua University,Beijing,China.,D. Radiology,Chinese Pla General Hospital,S. O. Sciences,North China University of Science,Technology,Tangshan,Hebei,Department of Electrical Engineering,Duke University,Durham,N. Carolina,Usa +20 more
TL;DR: A Hessian filter-assisted, adaptive thresholding vessel segmentation algorithm that demonstrates a superior and consistent accuracy of 0.987 regardless of kernel selection is developed and tested in two longitudinal studies on blood pressure agents.
Journal ArticleDOI
A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgery
TL;DR: A novel intra-operative navigation and sensing system that optimizes the functional accuracy of spinal pedicle screw implantation by incorporating radiation-free and multi-scale macroscopic 3D ultrasound (US) imaging and local tissue-awareness from in situ photoacoustic (PA) sensing at a clinically relevant mesoscopic scale is proposed.
Journal ArticleDOI
Transparent microfiber Fabry-Perot ultrasound sensor with needle-shaped focus for multiscale photoacoustic imaging.
TL;DR: In this article , a transparent polydimethylsiloxane (PDMS) encapsulated optical microfiber ultrasound sensor was demonstrated for multiscale and multimodal imaging with scalable spatial resolution and penetration depth.
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