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Photoacoustic microscopy: Photoacoustic microscopy

Junjie Yao, +1 more
- 01 Sep 2013 - 
- Vol. 7, Iss: 5, pp 758-778
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TLDR
Focusing on state-of-the-art developments in PAM, this Review discusses the key features of PAM implementations and their applications in biomedical studies.
Abstract
Photoacoustic microscopy (PAM) is a hybrid in vivo imaging technique that acoustically detects optical contrast via the photoacoustic effect. Unlike pure optical microscopic techniques, PAM takes advantage of the weak acoustic scattering in tissue and thus breaks through the optical diffusion limit (~1 mm in soft tissue). With its excellent scalability, PAM can provide high-resolution images at desired maximum imaging depths up to a few millimeters. Compared with backscattering-based confocal microscopy and optical coherence tomography, PAM provides absorption contrast instead of scattering contrast. Furthermore, PAM can image more molecules, endogenous or exogenous, at their absorbing wavelengths than fluorescence-based methods, such as wide-field, confocal, and multi-photon microscopy. Most importantly, PAM can simultaneously image anatomical, functional, molecular, flow dynamic and metabolic contrasts in vivo. Focusing on state-of-the-art developments in PAM, this Review discusses the key features of PAM implementations and their applications in biomedical studies.

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Citations
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Journal ArticleDOI

Reconstructing Undersampled Photoacoustic Microscopy Images Using Deep Learning

TL;DR: The results and numerical analysis have collectively demonstrated the robust performance of the model to reconstruct PAM images with as few as 2% of the original pixels, which can effectively shorten the imaging time without substantially sacrificing the image quality.
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Overview of Ultrasound Detection Technologies for Photoacoustic Imaging

TL;DR: An overview on various ultrasound transducer technologies including conventional piezoelectric and micromachined transducers, as well as optical ultrasound detection technology, explaining the core components of each technology, their working principle, and describe their manufacturing process.
Journal ArticleDOI

Semi-quantitative Multispectral Optoacoustic Tomography (MSOT) for volumetric PK imaging of gastric emptying

TL;DR: In this paper, a multispectral Optoacoustic Tomography (MSOT) was used to monitor gastrointestinal motility by in vivo whole body imaging in mice, where animals were given Indocyanine Green (ICG) by oral gavage and imaged by MSOT to observe the fate of ICG in the gastrointestinal tract.
Journal ArticleDOI

High-speed and high-SNR photoacoustic microscopy based on a galvanometer mirror in non-conducting liquid

TL;DR: This paper demonstrates a simple and novel OR-PAM technique which is based on a typical galvanometer immersed in non-conducting liquid and achieves a high SNR and fast imaging speed, and successfully imaged the microvasculature in a mouse ear in vivo.
Journal ArticleDOI

Multiscale Functional and Molecular Photoacoustic Tomography.

TL;DR: Integration of PAT with other imaging technologies provides complementary capabilities and can potentially accelerate the clinical translation of PAT.
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