Photoacoustic microscopy: Photoacoustic microscopy
Junjie Yao,Lihong V. Wang +1 more
Reads0
Chats0
TLDR
Focusing on state-of-the-art developments in PAM, this Review discusses the key features of PAM implementations and their applications in biomedical studies.Abstract:
Photoacoustic microscopy (PAM) is a hybrid in vivo imaging technique that acoustically detects optical contrast via the photoacoustic effect. Unlike pure optical microscopic techniques, PAM takes advantage of the weak acoustic scattering in tissue and thus breaks through the optical diffusion limit (~1 mm in soft tissue). With its excellent scalability, PAM can provide high-resolution images at desired maximum imaging depths up to a few millimeters. Compared with backscattering-based confocal microscopy and optical coherence tomography, PAM provides absorption contrast instead of scattering contrast. Furthermore, PAM can image more molecules, endogenous or exogenous, at their absorbing wavelengths than fluorescence-based methods, such as wide-field, confocal, and multi-photon microscopy. Most importantly, PAM can simultaneously image anatomical, functional, molecular, flow dynamic and metabolic contrasts in vivo. Focusing on state-of-the-art developments in PAM, this Review discusses the key features of PAM implementations and their applications in biomedical studies.read more
Citations
More filters
Journal ArticleDOI
Full-view in vivo skin and blood vessels profile segmentation in photoacoustic imaging based on deep learning.
Cao Duong Ly,Van Tu Nguyen,Tan Hung Vo,Sudip Mondal,Sumin Park,Jaeyeop Choi,Thi Thu Ha Vu,Chang-Seok Kim,Junghwan Oh +8 more
TL;DR: Wang et al. as discussed by the authors proposed a DL model based on modified U-Net for extracting the relationship features between amplitudes of the generated photoacoustic signal from skin and underlying vessels.
Journal ArticleDOI
Ultrasound and Photoacoustic Imaging of Breast Cancer: Clinical Systems, Challenges, and Future Outlook
TL;DR: An overview of available systems in the area of TUST and PAT are discussed along with their advantages and disadvantages in breast cancer diagnosis to provide a landscape of possible intersections and future refinements in cancer diagnosis.
Journal ArticleDOI
ADMM based low-rank and sparse matrix recovery method for sparse photoacoustic microscopy
TL;DR: An Alternating Direction Method of Multipliers (ADMM) based low-rank and sparse matrix recovery method for a sparse optical-scanning PAM system to realize fast PAM vascular imaging and demonstrates the preclinical and clinical potential of sparse Pam system in investigating vascular diseases.
Journal ArticleDOI
Whole-Cell Photoacoustic Sensor Based on Pigment Relocalization.
Antonella Lauri,Dominik Soliman,Murad Omar,Anja Stelzl,Vasilis Ntziachristos,Gil G. Westmeyer +5 more
TL;DR: A photoac acoustic pigment relocalization sensor (PaPiReS) is introduced for molecular photoacoustic imaging of GPCR-mediated signaling molecules of cuttlefish who can change their color by relocalizing pigment-filled organelles in so-called chromatophore cells under neurohumoral control.
Journal ArticleDOI
Ultra-widefield photoacoustic microscopy with a dual-channel slider-crank laser-scanning apparatus for in vivo biomedical study.
Van Tu Nguyen,Nguyen Thanh Phong Truong,Van Hiep Pham,Jaeyeop Choi,Sumin Park,Cao Duong Ly,Soon-Woo Cho,Sudip Mondal,Hae Gyun Lim,Chang-Seok Kim,Junghwan Oh +10 more
TL;DR: In this paper, a dual-channel photoacoustic microscopy (PAM) system based on a custom-made slider-crank scanner is presented. But, the system's spatial resolution is measured at ∼3.4μm and ∼37μm, respectively.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs
Lihong V. Wang,Song Hu +1 more
TL;DR: A review of the state of the art of photoacoustic tomography for both biological and clinical studies can be found in this paper, where the authors discuss the current state-of-the-art and discuss future prospects.
Journal ArticleDOI
Nanoparticle and targeted systems for cancer therapy.
TL;DR: This review explores recent work directed towards more targeted treatment of cancer, whether through more specific anti-cancer agents or through methods of delivery, including delivery by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-specific targeting.
Journal ArticleDOI
Nanoparticles in Medicine: Therapeutic Applications and Developments
TL;DR: Nanomaterials have unique physicochemical properties, such as ultra small size, large surface area to mass ratio, and high reactivity, which are different from bulk materials of the same composition, which can be used to overcome some of the limitations found in traditional therapeutic and diagnostic agents.