Journal ArticleDOI
Pigment Epithelial Detachment Followed by Retinal Cystoid Degeneration Leads to Vision Loss in Treatment of Neovascular Age-Related Macular Degeneration
Ursula Schmidt-Erfurth,Sebastian M. Waldstein,Gabor-Gyoergy Deak,Michael Kundi,Christian Simader +4 more
TLDR
The subretinal pigment epithelium lesion underlying PED appears to be the primary indicator for progressive disease activity, whereas secondary cystoid degeneration is the most relevant imaging marker for visual function.About:
This article is published in Ophthalmology.The article was published on 2015-04-01. It has received 156 citations till now. The article focuses on the topics: Macular degeneration & Ranibizumab.read more
Citations
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Journal ArticleDOI
Five-Year Outcomes with Anti-Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials
Maureen G. Maguire,Daniel F. Martin,Gui-Shuang Ying,Glenn J. Jaffe,Ebenezer Daniel,Juan E. Grunwald,Cynthia A. Toth,Frederick L. Ferris,Stuart L. Fine +8 more
TL;DR: Vision gains during the first 2 years were not maintained, but 50% of eyes had VA of 20/40 or better, confirming anti-vascular endothelial growth factor therapy as a major long-term therapeutic advance for neovascular AMD.
Journal ArticleDOI
Artificial intelligence in retina.
Ursula Schmidt-Erfurth,Amir Sadeghipour,Bianca S. Gerendas,Sebastian M. Waldstein,Hrvoje Bogunovic +4 more
TL;DR: In this paper, a fully automated AI-based system has been proposed for screening of diabetic retinopathy (DR) in diabetic macular and retinal disease using a convolutional neural network.
Journal ArticleDOI
Fully Automated Detection and Quantification of Macular Fluid in OCT Using Deep Learning
Thomas Schlegl,Sebastian M. Waldstein,Hrvoje Bogunovic,Franz Endstraßer,Amir Sadeghipour,Ana-Maria Philip,Dominika Podkowinski,Bianca S. Gerendas,Georg Langs,Ursula Schmidt-Erfurth +9 more
TL;DR: Deep learning in retinal image analysis achieves excellent accuracy for the differential detection of retinal fluid types across the most prevalent exudative macular diseases and OCT devices.
Journal ArticleDOI
A paradigm shift in imaging biomarkers in neovascular age-related macular degeneration.
TL;DR: Using innovative analysis methods, retinal biomarkers can be used to provide efficient personalized therapy for the individual patient, predictive disease- and population-based models for large-scale management and identifying promising targets for the development of novel therapeutic strategies.
Journal ArticleDOI
Tolerating subretinal fluid in neovascular age-related macular degeneration treated with ranibizumab using a treat-and-extend regimen: FLUID study 24-month results
Robyn H. Guymer,Caroline M. Markey,Ian L. McAllister,Mark C Gillies,Alex P. Hunyor,Jennifer J. Arnold,Fluid Investigators +6 more
TL;DR: Patients treated with a ranibizumab T&E protocol who tolerated some SRF achieved VA that is comparable, with fewer injections, with that achieved when treatment aimed to resolve all SRF completely.
References
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Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
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Nathan Nair,Luigi Naldi,K.M. Venkat Narayan,Paul K. Nelson,Robert G. Nelson,Michael C. Nevitt,Charles R. Newton,Sandra Nolte,Paul Norman,Rosana E. Norman,Martin O'Donnell,Simon J. O’Hanlon,Casey Olives,Saad B. Omer,Katrina F Ortblad,Richard H. Osborne,Doruk Ozgediz,Andrew Page,Bishnu Pahari,Jeyaraj D Pandian,Andrea Panozo Rivero,Scott B. Patten,Neil Pearce,Rogelio Perez Padilla,Fernando Perez-Ruiz,Norberto Perico,Konrad Pesudovs,David Phillips,Michael R. Phillips,Kelsey Pierce,Sébastien D. S. Pion,Guilherme V. Polanczyk,Suzanne Polinder,C. Arden Pope,Svetlana Popova,Esteban Porrini,Farshad Pourmalek,Martin Prince,Rachel L. Pullan,Kapa D. Ramaiah,Dharani Ranganathan,Homie Razavi,Mathilda Regan,Jürgen Rehm,David B. Rein,G. Remuzzi,Kathryn Richardson,Frederick P. Rivara,Thomas Roberts,Carolyn Robinson,Felipe Rodriguez De Leòn,Luca Ronfani,Robin Room,Lisa C. Rosenfeld,Lesley Rushton,Ralph L. Sacco,Sukanta Saha,Uchechukwu Sampson,Lidia Sanchez-Riera,Ella Sanman,David C. Schwebel,James Scott,Maria Segui-Gomez,Saeid Shahraz,Donald S. Shepard,Hwashin Shin,Rupak Shivakoti,Donald H. Silberberg,David Singh,Gitanjali M Singh,Jasvinder A. Singh,Jessica Singleton,David A. Sleet,Karen Sliwa,Emma Smith,Jennifer L. Smith,Nicolas J. C. Stapelberg,Andrew C Steer,Timothy J. Steiner,Wilma A. Stolk,Lars Jacob Stovner,Christopher R. Sudfeld,Sana Syed,Giorgio Tamburlini,Mohammad Tavakkoli,Hugh R. Taylor,Jennifer A. Taylor,William J. Taylor,Bernadette Thomas,W. Murray Thomson,George D. Thurston,Imad M. Tleyjeh,Marcello Tonelli,Jeffrey A. Towbin,Thomas Truelsen,Miltiadis K. Tsilimbaris,Clotilde Ubeda,Eduardo A. Undurraga,Marieke J. van der Werf,Jim van Os,Monica S. Vavilala,Narayanaswamy Venketasubramanian,Mengru Wang,Wenzhi Wang,Kerrianne Watt,David Weatherall,Martin A. Weinstock,Robert G. Weintraub,Marc G. Weisskopf,Myrna M. Weissman,Richard A. White,Harvey Whiteford,Steven T. Wiersma,James D. Wilkinson,Hywel C Williams,Sean R.M. Williams,Emma Witt,Frederick Wolfe,Anthony D. Woolf,Sarah Wulf,Pon Hsiu Yeh,Anita K. M. Zaidi,Zhi Jie Zheng,David Zonies,Alan D. Lopez,Christopher J L Murray +363 more
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
Journal ArticleDOI
Ranibizumab for Neovascular Age-Related Macular Degeneration
Philip J. Rosenfeld,David M. Brown,Jeffrey S. Heier,David S. Boyer,Peter K. Kaiser,Carol Chung,Robert Y. Kim +6 more
TL;DR: Intravitreal administration of ranibizumab for 2 years prevented vision loss and improved mean visual acuity, with low rates of serious adverse events, in patients with minimally classic or occult (with no classic lesions) choroidal neovascularization secondary to age-related macular degeneration.
Journal ArticleDOI
Ranibizumab versus Verteporfin for Neovascular Age-Related Macular Degeneration
David M. Brown,Peter K. Kaiser,Mark Michels,Gisèle Soubrane,Jeffrey S. Heier,Robert Y. Kim,Judy P. Sy,Susan Schneider +7 more
TL;DR: Ranibizumab was superior to verteporfin as intravitreal treatment of predominantly classic neovascular age-related macular degeneration, with low rates of serious ocular adverse events and treatment improved visual acuity on average at 1 year.
Journal ArticleDOI
Prevalence of age-related macular degeneration in the United States.
David S. Friedman,O'Colmain Bj,Beatriz Munoz,Sandra C. Tomany,Catherine A. McCarty,de Jong Pt,de Jong Pt,de Jong Pt,Barbara Nemesure,Paul Mitchell,Paul Mitchell,John H. Kempen +11 more
TL;DR: In this article, the prevalence and distribution of age-related macular degeneration (AMD) in the United States by age, race/ethnicity, and gender was estimated.
Journal ArticleDOI
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.
Jeffrey S. Heier,David M. Brown,Victor Chong,Jean-François Korobelnik,Peter K. Kaiser,Quan Dong Nguyen,Bernd Kirchhof,Allen C. Ho,Yuichiro Ogura,George D. Yancopoulos,Neil Stahl,Robert Vitti,Alyson J. Berliner,Yuhwen Soo,Majid Anderesi,Georg Groetzbach,Bernd Sommerauer,Rupert Sandbrink,Rupert Sandbrink,Christian Simader,Ursula Schmidt-Erfurth +20 more
TL;DR: It is demonstrated that aflibercept is an effective treatment for AMD, with the every-2-month regimen offering the potential to reduce the risk from monthly intravitreal injections and the burden of monthly monitoring.
Related Papers (5)
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.
Jeffrey S. Heier,David M. Brown,Victor Chong,Jean-François Korobelnik,Peter K. Kaiser,Quan Dong Nguyen,Bernd Kirchhof,Allen C. Ho,Yuichiro Ogura,George D. Yancopoulos,Neil Stahl,Robert Vitti,Alyson J. Berliner,Yuhwen Soo,Majid Anderesi,Georg Groetzbach,Bernd Sommerauer,Rupert Sandbrink,Rupert Sandbrink,Christian Simader,Ursula Schmidt-Erfurth +20 more