Platelets at the interface of thrombosis, inflammation, and cancer
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TLDR
The basic scientist studying platelet function can think beyond the traditional hemostasis and thrombosis paradigms, while the practicing hematologist must appreciate platelet relevance in a wide range of disease processes.About:
This article is published in Blood.The article was published on 2015-07-30 and is currently open access. It has received 450 citations till now. The article focuses on the topics: Platelet & Hemostasis.read more
Citations
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Emerging Biological Principles of Metastasis
TL;DR: The cellular and molecular mechanisms involved in metastasis are summarized, with a focus on carcinomas where the most is known, and the general principles of metastasis that have begun to emerge are highlighted.
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In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy
TL;DR: It is shown that conjugating anti-PDL1 (engineered monoclonal antibodies against programmed-death ligand 1) to the surface of platelets can reduce post-surgical tumour recurrence and metastasis, and that the administration of platelet-bound anti- PDL1 significantly prolonged overall mouse survival after surgery.
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Role of platelets and platelet receptors in cancer metastasis.
TL;DR: This review provides a synopsis on the current literature on Platelet-mediated effects in cancer metastasis and particularly focuses on platelet adhesion receptors and their role in metastasis.
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A conduit to metastasis: circulating tumor cell biology.
TL;DR: The study of CTCs has exposed dramatic intrapatient and interpatient heterogeneity and their evolution over time, and this review focuses on the current knowledge of C TC biology and the potential clinical implications.
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Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
Xiaohong Ruby Xu,Dan Zhang,Brigitta Elaine Oswald,Naadiya Carrim,Xiaozhong Wang,Yan Hou,Qing Zhang,Christopher Lavalle,Thomas McKeown,Alexandra H. Marshall,Heyu Ni +10 more
TL;DR: Recent studies demonstrated that fibrinogen-independent platelet aggregation occurs in both gene deficient animals and human patients under physiological and pathological conditions, which indicates that other unidentified platelet ligands may play important roles in thrombosis and might be novel antithrombotic targets.
References
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The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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