Journal ArticleDOI
Precipitating and perpetuating factors of rheumatoid arthritis immunopathology: linking the triad of genetic predisposition, environmental risk factors and autoimmunity to disease pathogenesis.
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TLDR
This article summarises the risk factors for RA development that have currently been identified, outlining the specific gene-environment and gene-gene interactions that may occur to precipitate and perpetuate autoimmunity and RA.Abstract:
Rheumatoid arthritis (RA) is considered to occur when genetic and environmental factors interact to trigger immunopathological changes and consequently an inflammatory arthritis. Over the last few decades, epidemiological and genetic studies have identified a large number of risk factors for RA development, the most prominent of which comprise cigarette smoking and the shared epitope alleles. These risks appear to differ substantially between anti-cyclic citrullinated peptide (ACPA)-positive and ACPA-negative disease. In this article, we will summarise the risk factors for RA development that have currently been identified, outlining the specific gene-environment and gene-gene interactions that may occur to precipitate and perpetuate autoimmunity and RA. We will also focus on how this knowledge of risk factors for RA may be implemented in the future to identify individuals at a high risk of disease development in whom preventative strategies may be undertaken.read more
Citations
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Journal ArticleDOI
Genetics of rheumatoid arthritis - A comprehensive review
TL;DR: Pharmacogenomics identified SNPs or multiple genetic signatures that may be associated with responses to traditional disease-modifying drugs and biologics.
Journal ArticleDOI
Smoking and overweight determine the likelihood of developing rheumatoid arthritis
Maria J. H. de Hair,Robert Landewé,Marleen G H van de Sande,Dirkjan van Schaardenburg,Lisa G. M. van Baarsen,Danielle M. Gerlag,Paul P. Tak +6 more
TL;DR: This is the first prospective study showing that smoking and overweight increase the risk of development of arthritis in a cohort of autoantibody-positive individuals at risk for developing RA.
Journal ArticleDOI
Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling.
Cheng-gui Miao,Ying-ying Yang,Xu He,Xiao-Feng Li,Cheng Huang,Yan Huang,Lei Zhang,Xiong-Wen Lv,Yong Jin,Jun Li +9 more
TL;DR: New advances of the Wnt signaling pathway in RA pathogenesis are discussed, with special emphasis on its different roles in synovial inflammation and bone remodeling.
Journal ArticleDOI
Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review
TL;DR: Different aspects of genetic involvement in the pathogenesis, etiology, and RA complications are reviewed in this article.
Journal ArticleDOI
Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies
Jing Shi,Peter A. van Veelen,Michael Mahler,George M.C. Janssen,Jan W. Drijfhout,Tom W J Huizinga,René E. M. Toes,Leendert A. Trouw +7 more
TL;DR: The presence of anti- Carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis patients and in patients having 'pre-RA' symptoms, arthralgia is identified and is associated with an increased risk of developing RA.
References
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Journal ArticleDOI
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
Noa Stanietsky,Hrvoje Šimić,Jurica Arapović,Amir Toporik,Ofer Levy,Amit Novik,Zurit Levine,Meirav Beiman,Liat Dassa,Hagit Achdout,Noam Stern-Ginossar,Pinhas Tsukerman,Stipan Jonjić,Ofer Mandelboim +13 more
TL;DR: It is shown that TIGIT is expressed by all human NK cells, that it binds PVR and PVRL2 but not PVRL3 and that it inhibits NK cytotoxicity directly through its ITIM, providing an “alternative self” mechanism for MHC class I inhibition.
Journal ArticleDOI
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.
TL;DR: Relation entre risque de pemphigus et DW1eme et DRW6eme, et relation entre susceptibilite a la polyarthrite rhumatoide and un groupe d'epitopes trouves dans les sous-types non DW10 de DR4.
Journal ArticleDOI
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.
Solbritt Rantapää-Dahlqvist,Ben A. W. de Jong,Ewa Berglin,Göran Hallmans,Göran Wadell,Hans Stenlund,Ulf Sundin,Walther J. van Venrooij +7 more
TL;DR: Anti-CCP antibody and RFs of all isotypes predated the onset of RA by several years, indicating that citrullination and the production of anti- CCP and RF autoantibodies are early processes in RA.
Journal ArticleDOI
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
Shigeru Kotake,Nobuyuki Udagawa,Naoyuki Takahashi,Kenichiro Matsuzaki,Kanami Itoh,Shigeru Ishiyama,Seiji Saito,Kazuhiko Inoue,Naoyuki Kamatani,Matthew T. Gillespie,T. John Martin,Tatsuo Suda +11 more
TL;DR: It is suggested that IL-17 first acts on osteoblasts, which stimulates both COX-2-dependent PGE2 synthesis and ODF gene expression, which in turn induce differentiation of osteoclast progenitors into mature osteoclasts, and that IL -17 is a crucial cytokine for osteoclastic bone resorption in RA patients.
Journal ArticleDOI
Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors
M M J Nielen,Dirkjan van Schaardenburg,Henk W. Reesink,Rob J. Van De Stadt,Irene E. van der Horst-Bruinsma,Margret H. M. T. De Koning,Moud R. Habibuw,Jan P. Vandenbroucke,Ben A. C. Dijkmans +8 more
TL;DR: In this article, the authors investigated the time course for the development of antibodies before onset of clinical RA and found that approximately half of patients with RA have specific serologic abnormalities several years before the onset of symptoms.
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