Journal ArticleDOI
Promiscuity of fibroblast growth factor receptors
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TLDR
The new findings suggest that in terms of ligand binding the FGFRs might be an even more promiscuous family of receptor tyrosine kinases than was already appreciated.Abstract:
Fibroblast growth factor receptors (FGFRs) have been implicated in many developmental and regenerative events, including axial organisation, mesodermal patterning, keratinocyte organisation and brain development. The consensus view that this reflects a role for one or other of the nine known members of the fibroblast growth factor family in these processes has recently been challenged by the suggestion that FGFRs might be directly activated by a much wider range of ligands, including heparan sulphate proteoglycans and neural cell adhesion molecules. In addition, two novel soluble ligands for FGFRs have been identified using yeast two-hybrid technology. Overall, the new findings suggest that in terms of ligand binding the FGFRs might be an even more promiscuous family of receptor tyrosine kinases than was already appreciated.read more
Citations
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Journal ArticleDOI
Reactive astrocytes: cellular and molecular cues to biological function
TL;DR: Reactive astrocytes should be considered a key element, like neurons, of a dynamic environment, thus forming with neurons a functional unit involved in homeostasis, plasticity and neurotransmission.
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Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins
TL;DR: Cell adhesion is critical for the genesis and maintenance of both three-dimensional structure and normal function in tissues and the biochemical entities mediating cell adhesion are multiprotein complexes comprising three broad classes of macromolecules.
Journal ArticleDOI
The roles of FGFs in the early development of vertebrate limbs
TL;DR: The purpose of this review is to discuss the functions performed by members of the FGF family in one of the best-studied vertebrate developmental systems—limb formation and discusses the potential role of FGFs in the induction of limb development.
PatentDOI
Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2
TL;DR: In this paper, it was shown that AAV requires human fibroblast growth factor receptor 1 (FGFR1) as a co-receptor for successful viral entry into the host cell.
Journal ArticleDOI
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
Xiaoling Xu,Michael Weinstein,Cuiling Li,Michael C. Naski,Rick I. Cohen,David M. Ornitz,Philip Leder,Chu-Xia Deng +7 more
TL;DR: Findings provide direct genetic evidence that FGF/FGFR2 signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction.
References
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Journal ArticleDOI
The heparin-binding (fibroblast) growth factor family of proteins.
Wilson H. Burgess,Thomas Maciag +1 more
Journal ArticleDOI
Developmental mechanisms that generate precise patterns of neuronal connectivity
Corey S. Goodman,Carla J. Shatz +1 more
TL;DR: The range of activityindependent and activity-dependent mechanisms that generate precision of neuronal connections is considered-the connections between motoneurons and muscles and between the retina and higher visual centers--to highlight the extent to which different parts of the nervous system use the same mechanisms but in different proportions to achieve the final specificity.
Book ChapterDOI
Structural and Functional Diversity in the FGf Receptor Multigene Family
Daniel Johnson,Lewis T. Williams +1 more
TL;DR: The characterization of structural and functional diversity within the F GF receptor shows the differences in the mechanisms of action among members of the FGF family.
Journal ArticleDOI
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
TL;DR: The results demonstrate that the FGF signaling pathway plays an important role in early embryogenesis, particularly in the formation of the posterior and lateral mesoderm.
Journal ArticleDOI
Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes
TL;DR: Article de synthese sur les glycosaminoglycanes chez les mammiferes: proprietes et structure des proteoglycane and des proteines de liaison des glycosaminaes.
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Structural and Functional Diversity in the FGf Receptor Multigene Family
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