Pyroptosis: mechanisms and diseases.
TLDR
It is described that pyroptosis is a double-edged sword for tumors and the rational use of this dual effect will help to further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroPTosis.Abstract:
Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptosis can affect the development of tumors. The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds. In this review, we provide basic knowledge of pyroptosis, explain the relationship between pyroptosis and tumors, and focus on the significance of pyroptosis in tumor treatment. In addition, we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis. In brief, pyroptosis is a double-edged sword for tumors. The rational use of this dual effect will help us further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroptosis.read more
Citations
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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria (111.33)
Edward A. Miao,Irina A. Leaf,Piper M. Treuting,Dat P. Mao,Anasuya Sarkar,Mark D. Wewers,Alan Aderem +6 more
TL;DR: It is demonstrated that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system.
The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting Natural killer cell tumoricidal activity
TL;DR: This work shows that mice deficient in Nlrp3 inflammasome components had exacerbated liver colorectal cancer metastatic growth, which was mediated by impaired interleukin-18 (IL-18) signaling.
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Gasdermin D exerts anti-inflammatory effects by promoting neutrophil death
Hiroto Kambara,Fei Liu,Xiaoyu Zhang,Xiaoyu Zhang,Peng Liu,Besnik Bajrami,Yan Teng,Li Zhao,Shiyi Zhou,Hongbo Yu,Weidong Zhou,Leslie E. Silberstein,Tao Cheng,Mingzhe Han,Yuanfu Xu,Hongbo R. Luo +15 more
TL;DR: Gasdermin D deficiency paradoxically augmented host responses to extracellular Escherichia coli, mainly by delaying neutrophil death, which established GSDMD as a negative regulator of innate immunity and a potential target for antibacterial and anti-inflammatory therapies.
Journal ArticleDOI
A Bibliometric Analysis of Pyroptosis From 2001 to 2021.
Dan Ma,Bin Yang,Baoyi Guan,Luxia Song,Qiyu Liu,Yixuan Fan,Lin Zhao,Tongxin Wang,Zihao Zhang,Zhuye Gao,Siming Li,Hao Xu +11 more
TL;DR: Wang et al. as mentioned in this paper visualize the research hotspots and trends of pyroptosis using a bibliometric analysis to help understand the future development of basic and clinical research.
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