Journal ArticleDOI
Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation.
TLDR
It is proposed here that Cdc25A, a dual specificity phosphatase crucial for cell cycle progression, is linked to connexin (Cx) phosphorylation and the modulation of GJC.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2005-02-25. It has received 21 citations till now. The article focuses on the topics: MAPK/ERK pathway & Tyrosine phosphorylation.read more
Citations
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Journal ArticleDOI
Connexins and their channels in cell growth and cell death
TL;DR: The current knowledge concerning the roles of connexins and their channels in the control of cellular homeostasis is summarized, with the emphasis on cell growth and cell death.
Journal ArticleDOI
Gap junctions and cancer: new functions for an old story.
TL;DR: By performing this analysis, it becomes clear that gap junctions are probably differently involved, depending on the stage of the cancer progression considered, and the most recent data suggest that connexins may act on cell growth by controlling gene expression through a variety of processes.
Journal ArticleDOI
Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer.
TL;DR: Emerging data in support of the role of estrogen induced ROS-mediated signaling pathways which may contribute in the development of breast cancer are discussed.
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1,4-naphthoquinones: from oxidative damage to cellular and inter-cellular signaling.
TL;DR: Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings.
Journal ArticleDOI
1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes.
Viola Klaus,Tobias Hartmann,Juan Gambini,Peter Graf,Wilhelm Stahl,Andrea Hartwig,Lars-Oliver Klotz,Lars-Oliver Klotz +7 more
TL;DR: Cytotoxic and oxidative action was paralleled by stimulation of stress signaling: all tested quinones except lawsone and lapachol strongly induced phosphorylation of the epidermal growth factor receptor (EGFR) and the related ErbB2 receptor tyrosine kinase.
References
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Journal ArticleDOI
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor.
TL;DR: It is found that the EGFRK activation loop adopts a conformation similar to that of the phosphorylated active form of the kinase domain from the insulin receptor, which is distinguished from all other known receptor tyrosine kinases in possessing constitutive kinase activity without a phosphorylation event within their kinase domains.
Journal ArticleDOI
Nuclear localization of EGF receptor and its potential new role as a transcription factor
Shiaw Yih Lin,Keishi Makino,Weiya Xia,Angabin Matin,Yong Wen,Ka Yin Kwong,Lilly Y.W. Bourguignon,Mien Chie Hung +7 more
TL;DR: It is demonstrated that nuclear EGFR is strongly correlated with highly proliferating activities of tissues and associated with promoter region of cyclin D1 in vivo, suggesting that EGFR might function as a transcription factor to activate genes required for highly proliferationating activities.
Journal ArticleDOI
An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors
Antony W. Burgess,Hyun Soo Cho,Hyun Soo Cho,Charles Eigenbrot,Kathryn M. Ferguson,Thomas P. J. Garrett,Thomas P. J. Garrett,Daniel J. Leahy,Mark A. Lemmon,Mark X. Sliwkowski,Colin W. Ward,Colin W. Ward,Shigeyuki Yokoyama +12 more
TL;DR: A mechanistic view of ErbB receptor homo- and heterodimerization is outlined, which suggests new approaches for interfering with these processes when they are implicated in human cancers.
Journal ArticleDOI
EGF Activates Its Receptor by Removing Interactions that Autoinhibit Ectodomain Dimerization
Kathryn M. Ferguson,Mitchell B. Berger,Jeannine M. Mendrola,Hyun Soo Cho,Daniel J. Leahy,Mark A. Lemmon +5 more
TL;DR: The structure reveals an autoinhibited configuration, where the dimerization interface recently identified in activated sEGFR structures is completely occluded by intramolecular interactions, which contrasts starkly with other RTK activation mechanisms and suggests new approaches for designing ErbB receptor antagonists.
Journal ArticleDOI
The effects of connexin phosphorylation on gap junctional communication.
Paul D. Lampe,Alan F. Lau +1 more
TL;DR: Since connexin43 (Cx43) is widely expressed in tissues and cell lines, it is understood the most about how it is regulated, and thus, con Nexin43 phosphorylation is a major focus of this review.
Related Papers (5)
Dual functions for connexins: Cx43 regulates growth independently of gap junction formation.
Catriona D. Moorby,Minal Patel +1 more