Open Access
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
Cristian Tomasetti,Cristian Tomasetti,Lu Li,Bert Vogelstein +3 more
- Vol. 5, Iss: 1, pp 79-86
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TLDR
An independent approach based solely on cancer genome sequencing and epidemiological data suggested that R mutations are responsible for two-thirds of the mutations in human cancers, and results are consistent with epidemiological estimates of the fraction of cancers that can be prevented by changes in the environment.Abstract:
Translation into Russian: Tomasetti, C. , Li, L. , & Vogelstein, B. (2017). Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention . Science , 355 (6331), 1330-1334. DOI: 10.1126/science.aaf9011read more
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Probabilistic Risk Assessment – The Keystone for the Future of Toxicology
Alexandra Maertens,Emily Golden,Thomas Luechtefeld,Sebastian Hoffmann,Katya Tsaioun,Thomas Hartung +5 more
TL;DR: An overview of methods for probabilistic risk assessment and their application for exposure assessment, physiologically-based kinetic modelling, probability of hazard assessment (based on quantitative and read-across based structure-activity relationships, and mechanistic alerts from in vitro studies), individual susceptibility assessment, and evidence integration can be found in this article .
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Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium
Manako Yamaguchi,Hirofumi Nakaoka,Kazuaki Suda,Keisuke Yoshihara,Tatsuya Ishiguro,Nozomi Yachida,K. Saito,Haruka Ueda,Kentaro Sugino,Yutaro Mori,Kaoru Yamawaki,Ryo Tamura,Sundaramoorthy Revathidevi,Teiichi Motoyama,Kazuki Tainaka,Roel G.W. Verhaak,Ituro Inoue,Takayuki Enomoto +17 more
TL;DR: In this article , the authors show that clonal expansions through the rhizome structures are involved in the mechanism by which mutant clones extend their territories in the normal endometrium.
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Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium
Manako Yamaguchi,Hirofumi Nakaoka,Kazuaki Suda,Keisuke Yoshihara,Tatsuya Ishiguro,Nozomi Yachida,K. Saito,Haruka Ueda,Kentaro Sugino,Yutaro Mori,Kaoru Yamawaki,Ryo Tamura,Sundaramoorthy Revathidevi,Teiichi Motoyama,Kazuki Tainaka,Roel G.W. Verhaak,Ituro Inoue,Takayuki Enomoto +17 more
TL;DR: In this paper , the authors show that clonal expansions through the rhizome structures are involved in the mechanism by which mutant clones extend their territories in the normal endometrium.
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Shared genetic and epigenetic changes link aging and cancer.
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Cellular and molecular mechanisms of plasticity in cancer.
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References
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Ahmed Jamal,Elyse Phillips,Andrea S. Gentzke,David M. Homa,Stephen Babb,Brian A. King,Linda J. Neff +6 more
TL;DR: To assess progress toward the Healthy People 2020 target of reducing the proportion of U.S. adults aged ≥18 years who smoke cigarettes to ≤12.0% (objective TU-1.1), the CDC analyzed data from the 2016 National Health Interview Survey (NHIS) and found that the prevalence of current cigarette smoking among adults was 15.5%, which was a significant decline from 2005 but no significant change has occurred since 2015.
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