Journal ArticleDOI
Release characteristics of diclofenac sodium from poly(vinyl alcohol)/sodium alginate and poly(vinyl alcohol)-grafted-poly(acrylamide)/sodium alginate blend beads.
Oya Şanlı,Nuran Ay,Nuran Işıklan +2 more
TLDR
It was observed that, DS release from the beads decreased with increasing PVA/NaAlg (m/m) ratio, drug/polymer ratio (d/p) and extent of cross-linking, but release increased with increasing acrylamide content of the PVA-g-PAAm polymer.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2007-02-01. It has received 150 citations till now. The article focuses on the topics: Controlled release & Polyvinyl alcohol.read more
Citations
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Journal ArticleDOI
Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery.
TL;DR: The state of the art of crosslinked ionic polysaccharides as components of delivery systems that can regulate drug release as a function of changes in pH, ion nature and concentration, electric and magnetic field intensity, light wavelength, temperature, redox potential, and certain molecules are analyzed.
Journal ArticleDOI
Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs
TL;DR: In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release, and the thickness of the blend nanofiber mats strongly influenced the initial release and rateof drug release.
Journal ArticleDOI
Development of pH-sensitive tamarind seed polysaccharide-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology.
Amit Kumar Nayak,Dilipkumar Pal +1 more
TL;DR: The newly developed TSP-alginate composite beads are suitable for controlled delivery of diclofenac sodium for prolonged period and their observed responses were coincided well with the predicted values by the experimental design.
Journal ArticleDOI
Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide
TL;DR: Solution pH, crosslinker concentration and monomer to SA weight ratio of the hydrogels were found to have a strong effect on adsorption and in vitro release profile of the drug from the gel matrix.
Journal ArticleDOI
In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matrices.
TL;DR: In this work, the nanocomposite beads prepared under optimum condition could prolong the release of DS for 8h more compared with the pristine SA hydrogel beads and the entrapment efficiency and release rate of DS was improved, and the burst release ofDS was overcome.
References
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Journal ArticleDOI
Release and diffusion of sulfamethoxazole through acrylamide‐based hydrogel
Anil Kumar Bajpai,M. Rajpoot +1 more
TL;DR: In this article, two polymeric hydrogels (xerogels) containing poly(vinyl pyrrolidone) (PVP)-crosslinked polyacrylamide and polyvinyl alcohol (PVA)-cross-linked polyACYlamide were loaded with the sulfamethoxazole drug and their swelling and drug-release dynamics were investigated at a fixed pH and at room temperature (27°C).
Journal ArticleDOI
On the restriction of the release of water-soluble component from polyvinyl alcohol film by blending β-cyclodextrin
TL;DR: In this paper, the effect of β-cyclodextrin with polyvinyl alcohol (PVA) hydrogel on the release of a water-soluble component has been investigated.
Journal ArticleDOI
Diclofenac sodium releasing pH-sensitive monolithic devices
TL;DR: A non-steroidal anti-inflammatory agent, diclofenac sodium (DFNa), was incorporated into the pH-sensitive monolithic systems prepared by crosslinking/copolymerization of 2-hydroxyethyl methacrylate with acrylate-based acidic and basic comonomers, i.e. acrylic acid (AA) and dimethylaminoethyl methACrylate (DMAEMA).
Journal ArticleDOI
Permeation and separation characteristics of acetic acid/water mixtures through poly(vinyl alcohol-g-itaconic acid) membranes by pervaporation, evapomeation, and temperature-difference evapomeation
Nuran Işıklan,Oya Şanlı +1 more
TL;DR: In this article, itaconic acid (IA) was grafted onto polyvinyl alcohol (PVA) with cerium(IV) ammonium nitrate as an initiator at 45°C.
Journal ArticleDOI
Preparation of chemically crosslinked gels with maleate-denatured poly(vinyl alcohol) and its application to drug release
TL;DR: In this article, a maleate-denatured polyvinyl alcohol (M-PVA) was crosslinked with heating and the mechanism of crosslinking was studied with several procedures: titration, Fourier transform infrared, and solubility.