Journal ArticleDOI
Release characteristics of diclofenac sodium from poly(vinyl alcohol)/sodium alginate and poly(vinyl alcohol)-grafted-poly(acrylamide)/sodium alginate blend beads.
Oya Şanlı,Nuran Ay,Nuran Işıklan +2 more
TLDR
It was observed that, DS release from the beads decreased with increasing PVA/NaAlg (m/m) ratio, drug/polymer ratio (d/p) and extent of cross-linking, but release increased with increasing acrylamide content of the PVA-g-PAAm polymer.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2007-02-01. It has received 150 citations till now. The article focuses on the topics: Controlled release & Polyvinyl alcohol.read more
Citations
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Journal ArticleDOI
Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery.
TL;DR: The state of the art of crosslinked ionic polysaccharides as components of delivery systems that can regulate drug release as a function of changes in pH, ion nature and concentration, electric and magnetic field intensity, light wavelength, temperature, redox potential, and certain molecules are analyzed.
Journal ArticleDOI
Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs
TL;DR: In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release, and the thickness of the blend nanofiber mats strongly influenced the initial release and rateof drug release.
Journal ArticleDOI
Development of pH-sensitive tamarind seed polysaccharide-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology.
Amit Kumar Nayak,Dilipkumar Pal +1 more
TL;DR: The newly developed TSP-alginate composite beads are suitable for controlled delivery of diclofenac sodium for prolonged period and their observed responses were coincided well with the predicted values by the experimental design.
Journal ArticleDOI
Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide
TL;DR: Solution pH, crosslinker concentration and monomer to SA weight ratio of the hydrogels were found to have a strong effect on adsorption and in vitro release profile of the drug from the gel matrix.
Journal ArticleDOI
In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matrices.
TL;DR: In this work, the nanocomposite beads prepared under optimum condition could prolong the release of DS for 8h more compared with the pristine SA hydrogel beads and the entrapment efficiency and release rate of DS was improved, and the burst release ofDS was overcome.
References
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Journal ArticleDOI
Preparation and Characterization of Binary Grafted Polymeric Blends of Polyvinyl Alcohol and Gelatin and Evaluation of their Water Uptake Potential
Anil Kumar Bajpai,Manish Sharma +1 more
TL;DR: In this paper, a binary hydrophilic blend of poly(acrylamide•co−methylene bis acrylamides) grafted polyvinyl alcohol (PVA) and gelatin (GEL) was prepared by redox polymerization method and the end product was characterized by infra red (IR) spectral analysis, differential scanning calorimety (DSC) measurements, and scanning electron micrograph (SEM).
Journal ArticleDOI
Hydrogels Formed by Crosslinked Poly(vinyl alcohol) as Sustained Drug Delivery Systems.
Isabella Orienti,R. Treré,Barbara Luppi,Federica Bigucci,Teresa Cerchiara,Guendalina Zuccari,Vittorio Zecchi +6 more
TL;DR: The degree of crosslinking of ethylene glycol diglycidyl ether and the extent of substitution with oleoyl chloride were found to influence drug release and indicated that the crosslinked polymers slowed down the release of the drugs with respect to the pure drug at each pH.
Journal ArticleDOI
Release of diclofenac through gluteraldehyde crosslinked poly(vinyl alcohol)/poly(acrylic acid) alloy membranes
Oya Şanlı,Gülsen Asman +1 more
TL;DR: In this paper, a controlled-release preparation of diclofenac sodium for transdermal administration has been developed using polyvinyl alcohol (PVA) and PVA/poly(acrylic acid) alloy membranes.
Journal ArticleDOI
In-vitro studies of enteric coated diclofenac sodium-carboxymethylcellulose microspheres
TL;DR: MIcrospheres containing diclofenac sodium (DS) were prepared using carboxymethylcellulose (CMC) as the main support material and aluminum chloride as the crosslinker and it was observed that increasing the CMC concentration led to an increase in the encapsulation efficiency, % yield value and particle size and decreased the release rate.
Journal ArticleDOI
Controlled release formulations of carbaryl based on copper alginate, barium alginate, and alginic acid beads
Oya Şanlı,Nuran Işıklan +1 more
TL;DR: In this paper, a controlled release system for reducing environmental impact was produced by encapsulating the pesticide carbaryl (Carb) in the alginate beads, and the surface morphology of prepared beads was characterized with scanning electron microscopy (SEM).