Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
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Social and behavioural determinants of areca nut consumption in adolescents
TL;DR: Investigation of the prevalence of areca nut consumption and social and behavioural determinants among a Taiwanese adolescent population found chewing habit was more prevalent among older adolescents, and future investigations into neurocognitive influences of risk taking behaviour and social dependence of the habit are indicated.
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Proteomic analysis of oral cancer reveals new potential therapeutic targets involved in the Warburg effect.
Yi Ping Huang,Nai Wen Chang +1 more
TL;DR: It is found that activation of PPARα through fenofibrate could inhibit oral cancer cell growth and switch the way of energy production from the Warburg effect to oxidative phosphorylation.
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Evaluation of the toxic potential of arecoline toward the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9
TL;DR: The results suggest that arecoline is toxic at 20, 40, and 80 μM toward the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9 .
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Immunohistochemical detection of 8-hydroxydeoxyguanosine: A biomarker of oxidative DNA damage in oral submucous fibrosis.
TL;DR: This is the first attempt to evaluate the expression of 8-OHdG in tissue samples that revealed the role of free radicals and oxidative DNA damage which enhances the initiation and progression of Oral submucous fibrosis.
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Fifty Years Research Output in Oral Submucous Fibrosis, A Bibliometric Analysis of Publications from 1967 to 2016
TL;DR: The results indicate that highest growth rate of publications occurred between the years 1997-2006 and India’s research share, citation score and h index was highest among all countries.
References
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Prooxidant states and tumor promotion.
TL;DR: Prooxidant states can be caused by different classes of agents, including hyperbaric oxygen, radiation, xenobiotic metabolites and Fenton-type reagents, modulators of the cytochrome P-450 electron-transport chain, peroxisome proliferators, inhibitors of the antioxidant defense, and membrane-active agents.
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
TL;DR: DCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base, and the potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion.
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Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
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Apoptosis in cancer
Scott W. Lowe,Athena W. Lin +1 more
TL;DR: An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
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Free radicals as mediators of tissue injury and disease.
TL;DR: This review discusses cellular sources of various radical species and their reactions with vital cellular constituents to provide insights into the controversy over whether free radicals are important mediators of tissue injury.