Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
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Areca nut is associated with younger age of diagnosis, poor chemoradiotherapy response, and shorter overall survival in esophageal squamous cell carcinoma.
Chang-Han Chen,Hung-I Lu,Yu-Ming Wang,Yen-Hao Chen,Chien-Ming Lo,Wan-Ting Huang,Shau-Hsuan Li +6 more
TL;DR: It is indicated that areca nut chewing history is significantly associated with younger age of onset, poor response to chemoradiotherapy, and shorter overall survival in ESCC patients.
Journal ArticleDOI
Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu).
TL;DR: The PAC distribution in areca nut was found to be very similar to that in grape seed, but lacking any gallate conjugates, and the accuracy and repeatability were within 10% for each analyte.
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Palauans who chew betel nut: social impact of oral disease.
TL;DR: The perceptions of betel-chewing Palauans in Hawaii regarding betel nut are described to determine the social impact of oral disease among these individuals and nurses face challenges in educating Palauan about the negative aspects of beteel nut, particularly those related to oral health especially when they do not perceive problems.
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Effects of areca nut extract on the apoptosis pathways in human neutrophils.
Weng Hang Ho,Yi Yen Lee,Lien Yu Chang,Yuan-Tsong Chen,Tsung-Yun Liu,Tsung-Yun Liu,Shan Ling Hung,Shan Ling Hung +7 more
TL;DR: Areca nut may regulate death pathways in neutrophils and this may be one mechanism by which areca nut compromises the periodontal health of areca Nut chewers.
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Arecoline N-oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions.
Tzer-Min Kuo,Srinivasan Nithiyanantham,Chi-Pin Lee,Hui-Ting Hsu,Shun-Yuan Luo,You-Zhe Lin,Kun-Tu Yeh,Ying-Chin Ko +7 more
TL;DR: The findings show that ANO exhibited higher toxicity in OPMD activity and play a significant role in the induction of areca nut mediated oral tumorigenesis.
References
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Prooxidant states and tumor promotion.
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
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Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
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Apoptosis in cancer
Scott W. Lowe,Athena W. Lin +1 more
TL;DR: An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
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Free radicals as mediators of tissue injury and disease.
TL;DR: This review discusses cellular sources of various radical species and their reactions with vital cellular constituents to provide insights into the controversy over whether free radicals are important mediators of tissue injury.