Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
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G1/S-specific cyclin-D1 might be a prognostic biomarker for patients with laryngeal squamous cell carcinoma.
TL;DR: Overexpression of cyclin-D1 can be used as a marker to predict relapse in patients with LSCC after primary curative resection and is correlated to shorter relapse-free survival period.
Journal Article
Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma.
Hua Yang,Chuzi Mo,Yang Xun,Leyna G Liu,Wen-Xing Li,Wen-Xing Li,Jieying Guan,Jing Liu,Jianquan Wu,Anping Yang,Song Guo Zheng,Dahai Liu,Fang Liu +12 more
TL;DR: It is demonstrated that Met/HGF expression results in OSCC resistance to cetuximab and tumor recurrence after cetUXimab therapy; thus, inhibition of Met/ HGF activity could restore OSCC sensitivity to cetusimab.
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Comparative study of oral micronucleated cell frequency in oral submucous fibrosis patients and healthy individuals
TL;DR: Micronuclei test can be used as an early indicator of genotoxicity in oral submucous fibrosis patients compared to healthy individuals and with gutkha chewing habit in younger age, chances of malignant transformation are high relatively.
Journal ArticleDOI
Effects of Betel Quid, Smoking and Alcohol on Oral Cancer Risk: A Case-Control Study in Hunan Province, China
TL;DR: There was a positive correlation between betel quid chewing and risk of oral cancer in the Hunan Province and the risk of cancer was significantly elevated at high levels of intake and prolonged duration of consumption of betelQuid, smoking, and alcohol.
Journal ArticleDOI
Evaluation of blueberry juice in mouse azoxymethane-induced aberrant crypts and oxidative damage.
Isela Álvarez-González,Fernando Garcia-Melo,Verónica R. Vásquez-Garzón,Saúl Villa-Treviño,E. Osiris Madrigal-Santillán,José A. Morales-González,Jorge A. Mendoza-Pérez,Eduardo Madrigal-Bujaidar +7 more
TL;DR: The results show a complex differential effect of BJ related to the tested doses, opening the need to further evaluate a number of factors so as to determine the possibility of a cocarcinogenic potential.
References
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Prooxidant states and tumor promotion.
TL;DR: Prooxidant states can be caused by different classes of agents, including hyperbaric oxygen, radiation, xenobiotic metabolites and Fenton-type reagents, modulators of the cytochrome P-450 electron-transport chain, peroxisome proliferators, inhibitors of the antioxidant defense, and membrane-active agents.
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
TL;DR: DCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base, and the potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion.
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Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
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Apoptosis in cancer
Scott W. Lowe,Athena W. Lin +1 more
TL;DR: An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
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Free radicals as mediators of tissue injury and disease.
TL;DR: This review discusses cellular sources of various radical species and their reactions with vital cellular constituents to provide insights into the controversy over whether free radicals are important mediators of tissue injury.