Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
Citations
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Journal ArticleDOI
The enigmatic epidemiology of nasopharyngeal carcinoma.
Ellen T. Chang,Hans-Olov Adami +1 more
TL;DR: There is a clear need for large-scale, population-based molecular epidemiologic studies to elucidate how environmental, viral, and genetic factors interact in both the development and the prevention of this disease.
Journal ArticleDOI
Oral submucous fibrosis: review on aetiology and pathogenesis.
Wanninayake Mudiyanselage Tilakaratne,M.F. Klinikowski,Takashi Saku,Tim J Peters,Saman Warnakulasuriya +4 more
TL;DR: Current evidence implicates collagen-related genes in the susceptibility and pathogenesis of OSF and the individual mechanisms operating at various stages of the disease-initial, intermediate and advanced need further study in order to propose appropriate therapeutic interventions.
Journal ArticleDOI
Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms
TL;DR: Evidence that strongly supports causative mechanisms for genotoxicity and carcinogenicity of these substitute products, including gutkha and pan masala, are strongly implicated in the recent increase in the incidence of oral submucous fibrosis is reviewed.
Journal ArticleDOI
Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men
Ariana Znaor,Paul Brennan,Vendhan Gajalakshmi,Aleyamma Mathew,Viswanathan Shanta,C Varghese,Paolo Boffetta +6 more
TL;DR: A significant dose‐response relationship for duration and amount of consumption of the 3 habits with the development of the above 3 neoplasms was observed and significant decreases in risks for all 3 cancer sites were observed in subjects who quit smoking even among those who had quit smoking 2–4 years before the interview.
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Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
Yin Ju Chen,Joseph Tung-Chieh Chang,Joseph Tung-Chieh Chang,Chun Ta Liao,Chun Ta Liao,Hung-Ming Wang,Hung-Ming Wang,Tzu Chen Yen,Tzu Chen Yen,Ching Chi Chiu,Ya Ching Lu,Hsiao Fang Li,Ann-Joy Cheng +12 more
TL;DR: The molecular and cellular aspects of HNC carcinogenesis in Taiwan, an endemic betel quid chewing area, are discussed, which may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics.
References
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Journal ArticleDOI
Mutagenicity of betel quid and its ingredients using mammalian test systems.
TL;DR: The mutagenic potential of betel quid and its ingredients (known colloquially as PAN) were tested in two short term mutagenicity assays, the micronucleus test and a mammalian gene mutation test and the data presented correlate well with previous tumorigenicity data on these compounds.
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A study of betel quid carcinogenesis. IV. Analysis of the saliva of betel chewers: a preliminary report.
TL;DR: This article found N-nitrosoguvacoline in the saliva of betel-quid chewers (2.2-350 ppb) when the quid contains tobacco, N′-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (1.0-2.3 ppb), and N′-(nitrosoanatabine) (3.2−39.5 ppb).
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Inflammation, Oxidative DNA Damage, and Carcinogenesis
J G Lewis,D O Adams +1 more
TL;DR: In vivo studies demonstrated that SENCAR mice, which are sensitive to promotion by TPA, have a more intense inflammatory reaction in skin than C57LB/6 mice,Which are resistant to promotion to this nongenotoxic agent.
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Carcinogenic Effect of a Dimethyl Sulphoxide Extract of Betel Nut on the Mucosa of the Hamster Buccal Pouch
TL;DR: It is found that repeated, topical applications of DMSO extracts of betel nut to the mucosa of the buccal pouch of hamsters result in the development of leukoplakia and tumours.
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Inhibition of the migration, attachment, spreading, growth and collagen synthesis of human gingival fibroblasts by arecoline, a major areca alkaloid, in vitro
TL;DR: Because of repeated and long-term exposure to arecoline, BQ chewers could be more susceptible to periodontal damage and less responsive to new attachment procedures.