Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
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CYCLOOXYGENASE-2 (COX-2) EXPRESSION ON TESTIS CONNECTIVE TISSUE OF Rattus norvegicusAFTER TREATMENT WITH BETEL NUT EXTRACT (Areca catechu)
Muslim Akmal,Wibi Riawan +1 more
TL;DR: The result showed that dose variation of betel nut extract could induction of COX-2 expression on rats (Rattus norvegicus) strain Wistar testicular seminiferous tubule.
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Current Novel Concept of Carcinogenesis to Combat Oral Cancer
TL;DR: Novel approaches, such as interventions with molecularly targeted agents and drug combinations in high-risk oral patients, are undoubtedly needed to reduce the devastating global consequences of oral malignancy.
Efeito apoptótico do extrato bruto de tabaco em linhagem de
TL;DR: Investigation of the cytotoxic effects of tobacco crude extract and 5 fractions thereof on a human oral squamous cell carcinoma indicates that although tobacco is a known carcinogen, possessing many tumorinitiating compounds, it could also contain compounds that are useful to induce apoptosis in cancer cells.
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Tea and oral cancer: a review
TL;DR: The present review focuses on the tea antioxidants and their mechanism of protective effects on oral cancer.
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Molecular mechanisms of oral submucous fibrosis and oral cancer: A review
Ashwini Dhopte,Hiroj Bagde +1 more
TL;DR: Chewing betel quid (BQ) increases the risk of oral cancer and oral submucous fibrosis (OSMF), a potentially malignant oral premalignant condition (OPMD) as discussed by the authors .
References
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
TL;DR: DCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base, and the potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion.
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Oxyradicals and DNA damage
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Apoptosis in cancer
Scott W. Lowe,Athena W. Lin +1 more
TL;DR: An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
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Free radicals as mediators of tissue injury and disease.
TL;DR: This review discusses cellular sources of various radical species and their reactions with vital cellular constituents to provide insights into the controversy over whether free radicals are important mediators of tissue injury.