Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
Citations
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Journal ArticleDOI
Persistence of leader cell behaviour can lead to malignant transformation in oral submucous fibrosis
TL;DR: The persistence of leader cells in the oral epithelial population could be a major driver for malignant transformation in OSMF and a determinant of intra-tumoral heterogeneity as discussed by the authors .
Patent
Nouvelle composition de rafraîchissement d'haleine et ses procédés de préparation
TL;DR: The authors concerne un processus de preparation de noix de cola with caracteristiques de difficulte a mordre, de rafraichissement and de stimulation similaires.
Amino Acid Profile in Oral Submucous Fibrosis: A High Performance Liquid Chromatography (HPLC) Study Dentistry Section
Richa Goel,J. SheRlin +1 more
TL;DR: A few amino acids have been identified which can be used as biological markers for the severity of the disease such as valine, methionine and phenyl alanine, which are required to elucidate the potential of these biological markers.
Journal ArticleDOI
Prevalence of Non-tobacco Associated Tongue Squamous Cell Carcinoma - Retrospective Study
TL;DR: This poster presents a probabilistic procedure called “Sivakumar’s procedure”, where a single excision is performed on the back of the neck to correct for toothache after surgery.
Book ChapterDOI
Role of Brachytherapy in Treatment of Head and Neck Malignancy
TL;DR: Brachytherapy permits dose intensification specifically to the tumor site while minimizing damage to the surrounding normal tissue and organs, which leads to an increased therapeutic ratio, while the patient also stands to gain functionally, psychologically, and cosmetically.
References
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Journal ArticleDOI
Prooxidant states and tumor promotion.
TL;DR: Prooxidant states can be caused by different classes of agents, including hyperbaric oxygen, radiation, xenobiotic metabolites and Fenton-type reagents, modulators of the cytochrome P-450 electron-transport chain, peroxisome proliferators, inhibitors of the antioxidant defense, and membrane-active agents.
Journal ArticleDOI
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
TL;DR: DCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base, and the potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion.
Journal ArticleDOI
Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
Journal ArticleDOI
Apoptosis in cancer
Scott W. Lowe,Athena W. Lin +1 more
TL;DR: An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
Journal ArticleDOI
Free radicals as mediators of tissue injury and disease.
TL;DR: This review discusses cellular sources of various radical species and their reactions with vital cellular constituents to provide insights into the controversy over whether free radicals are important mediators of tissue injury.