Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
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Dissertation
Inter-Individual Variation in Saliva Antioxidant Status in Relation to Periodontal Disease
TL;DR: It is suggested that severe PD is associated with a decreased salivary antioxidant flow rate and increased oxidative injury, and dietary antioxidant supplementation does not appear to increase salivARY antioxidant status as it does in plasma.
Journal ArticleDOI
Hispolon induces apoptosis in oral squamous cell carcinoma cells through JNK/HO‐1 pathway activation
Wei-En Yang,Yi-Tzu Chen,Chun-Wen Su,Mu-Kuan Chen,Chia-Ming Yeh,Yen-Lin Chen,Meng-Ying Tsai,Shun-Fa Yang,Chiao‐Wen Lin +8 more
TL;DR: In this article , the authors used the cell viability assay, clonogenic assay, fluorescent nuclear staining, and flow cytometry assay to analyse the apoptosis-inducing effects of hispolon in OSCC cells.
Journal ArticleDOI
Areca nut extract (ANE) inhibits the progression of hepatocellular carcinoma cells via activation of ROS production and activation of autophagy.
TL;DR: In this paper, the therapeutic effect of areca nut extract (ANE) on hepatocellular carcinoma (HCC) was investigated in mice and showed that ANE treatment caused a reduction in cell viability and an increase in cell apoptosis and suppressed tumor progression in xenograft models.
Journal ArticleDOI
Comparison of the psychoactive activity of four primary Areca nut alkaloids in zebrafish by behavioral approach and molecular docking.
Petrus Siregar,Gilbert Audira,Agnes L. Castillo,Marri Jmelou M. Roldan,Michael Edbert Suryanto,Rong-Xuan Liu,Ying Lin,Yu-Heng Lai,Chung-Der Hsiao +8 more
TL;DR: In this paper , the effects of four primary alkaloids (arecoline, arecaidine, guvacine, and guvacanoline) isolated from areca nut on zebrafish larvae were investigated.
References
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Journal ArticleDOI
Prooxidant states and tumor promotion.
TL;DR: Prooxidant states can be caused by different classes of agents, including hyperbaric oxygen, radiation, xenobiotic metabolites and Fenton-type reagents, modulators of the cytochrome P-450 electron-transport chain, peroxisome proliferators, inhibitors of the antioxidant defense, and membrane-active agents.
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
TL;DR: DCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base, and the potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion.
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Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
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Apoptosis in cancer
Scott W. Lowe,Athena W. Lin +1 more
TL;DR: An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
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Free radicals as mediators of tissue injury and disease.
TL;DR: This review discusses cellular sources of various radical species and their reactions with vital cellular constituents to provide insights into the controversy over whether free radicals are important mediators of tissue injury.