Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
Citations
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Journal ArticleDOI
The enigmatic epidemiology of nasopharyngeal carcinoma.
Ellen T. Chang,Hans-Olov Adami +1 more
TL;DR: There is a clear need for large-scale, population-based molecular epidemiologic studies to elucidate how environmental, viral, and genetic factors interact in both the development and the prevention of this disease.
Journal ArticleDOI
Oral submucous fibrosis: review on aetiology and pathogenesis.
Wanninayake Mudiyanselage Tilakaratne,M.F. Klinikowski,Takashi Saku,Tim J Peters,Saman Warnakulasuriya +4 more
TL;DR: Current evidence implicates collagen-related genes in the susceptibility and pathogenesis of OSF and the individual mechanisms operating at various stages of the disease-initial, intermediate and advanced need further study in order to propose appropriate therapeutic interventions.
Journal ArticleDOI
Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms
TL;DR: Evidence that strongly supports causative mechanisms for genotoxicity and carcinogenicity of these substitute products, including gutkha and pan masala, are strongly implicated in the recent increase in the incidence of oral submucous fibrosis is reviewed.
Journal ArticleDOI
Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men
Ariana Znaor,Paul Brennan,Vendhan Gajalakshmi,Aleyamma Mathew,Viswanathan Shanta,C Varghese,Paolo Boffetta +6 more
TL;DR: A significant dose‐response relationship for duration and amount of consumption of the 3 habits with the development of the above 3 neoplasms was observed and significant decreases in risks for all 3 cancer sites were observed in subjects who quit smoking even among those who had quit smoking 2–4 years before the interview.
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Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
Yin Ju Chen,Joseph Tung-Chieh Chang,Joseph Tung-Chieh Chang,Chun Ta Liao,Chun Ta Liao,Hung-Ming Wang,Hung-Ming Wang,Tzu Chen Yen,Tzu Chen Yen,Ching Chi Chiu,Ya Ching Lu,Hsiao Fang Li,Ann-Joy Cheng +12 more
TL;DR: The molecular and cellular aspects of HNC carcinogenesis in Taiwan, an endemic betel quid chewing area, are discussed, which may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics.
References
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Journal ArticleDOI
Ultrastructural findings in the oral mucosa of betel chewers.
TL;DR: While some of the ultrastructural findings in the epithelium of betel chewers are indicative of early dysplastic changes, the nature of the juxta-epithelial stromal alterations is still unknown.
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Study of unscheduled DNA synthesis following exposure of human cells to arecoline and extracts of betel nut in vitro
Rajeshwar N. Sharan,K. K. Wary +1 more
TL;DR: Results indicate that the aqueous and acetic acid extracts of betel nut induce relatively more unscheduled DNA synthesis than the hydrochloric acid and ethanol extracts and arecoline.
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Genotoxic effect of arecoline given either by the peritoneal or oral route in murine bone marrow cells and the influence of N-acetylcysteine.
Anupam Chatterjee,Shampa Deb +1 more
TL;DR: The data indicate that ARC-OA induced a higher frequency of cancers, a greater delay in the cell cycle and greater sister chromatid exchanges than ARC-IP.
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Promoting activity of betel quid ingredients and their inhibition by retinol
H.F. Stich,S.S. Tsang +1 more
TL;DR: Ingredients of betel quids, which have been linked to the high incidence of precancerous oral lesions and oral cancers, were examined for their promoting activity and the addition of retinol to the areca nut extract inhibited its tumour promoting effect in a dose-dependent manner.
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Studies on oral submucous fibrosis. III. Epithelial changes.
N.J. Mani,Baldev B. Singh +1 more
TL;DR: It was seen that in submucous fibrosis there is a tendency toward epithelial atrophy associated with hyperothokeratosis and pyknotic changes in the nuclei of the basal-cell layer, and the absence of glycogen from most of the Grade III (severe) cases was a striking feature.