Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
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Oral submucous fibrosis: an overview of the aetiology, pathogenesis, classification, and principles of management
Gururaj Arakeri,Peter A. Brennan +1 more
TL;DR: All components of OSMF are reviewed, including the terminology, presentation, aetiology, and pathogenesis, and a brief overview of its management are provided.
Journal Article
Oral submucous fibrosis―a review
TL;DR: Oral submucous fibrosis (OSF) affects an estimated 2.5 million people, mostly in the Indian subcontinent as mentioned in this paper. Limitation of oral opening resulting in difficulty in eating is the main presenting feature.
Journal ArticleDOI
Carcinoma and dysplasia in oral leukoplakias in Taiwan: prevalence and risk factors.
Jang-Jaer Lee,Hsin-Chia Hung,Shi-Jung Cheng,Yi-Jane Chen,Chun-Pin Chiang,Bu-Yuan Liu,Jiiang-Huei Jeng,Hao-Hueng Chang,Ying-Shiung Kuo,Wan-Hong Lan,Sang-Heng Kok +10 more
TL;DR: The results demonstrate that some leukoplakias contain a malignant component and should be submitted to microscopic analysis before any definite treatment or long-term follow-up.
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Areca nut and betel quid chewing among South Asian immigrants to Western countries and its implications for oral cancer screening
TL;DR: An overview of the sociocultural beliefs, knowledge and practices regarding betel quid/areca nut chewing is presented, and its implications for oral cancer screening among this immigrant population are discussed.
Journal ArticleDOI
Areca nut in pathogenesis of oral submucous fibrosis: revisited.
Punnya V. Angadi,Sanjay S. Rao +1 more
TL;DR: An overview on the role of areca nut in the pathogenesis and malignant potential of oral submucous fibrosis is given.
References
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
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Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
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Apoptosis in cancer
Scott W. Lowe,Athena W. Lin +1 more
TL;DR: An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
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Free radicals as mediators of tissue injury and disease.
TL;DR: This review discusses cellular sources of various radical species and their reactions with vital cellular constituents to provide insights into the controversy over whether free radicals are important mediators of tissue injury.