Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
Citations
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The enigmatic epidemiology of nasopharyngeal carcinoma.
Ellen T. Chang,Hans-Olov Adami +1 more
TL;DR: There is a clear need for large-scale, population-based molecular epidemiologic studies to elucidate how environmental, viral, and genetic factors interact in both the development and the prevention of this disease.
Journal ArticleDOI
Oral submucous fibrosis: review on aetiology and pathogenesis.
Wanninayake Mudiyanselage Tilakaratne,M.F. Klinikowski,Takashi Saku,Tim J Peters,Saman Warnakulasuriya +4 more
TL;DR: Current evidence implicates collagen-related genes in the susceptibility and pathogenesis of OSF and the individual mechanisms operating at various stages of the disease-initial, intermediate and advanced need further study in order to propose appropriate therapeutic interventions.
Journal ArticleDOI
Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms
TL;DR: Evidence that strongly supports causative mechanisms for genotoxicity and carcinogenicity of these substitute products, including gutkha and pan masala, are strongly implicated in the recent increase in the incidence of oral submucous fibrosis is reviewed.
Journal ArticleDOI
Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men
Ariana Znaor,Paul Brennan,Vendhan Gajalakshmi,Aleyamma Mathew,Viswanathan Shanta,C Varghese,Paolo Boffetta +6 more
TL;DR: A significant dose‐response relationship for duration and amount of consumption of the 3 habits with the development of the above 3 neoplasms was observed and significant decreases in risks for all 3 cancer sites were observed in subjects who quit smoking even among those who had quit smoking 2–4 years before the interview.
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Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
Yin Ju Chen,Joseph Tung-Chieh Chang,Joseph Tung-Chieh Chang,Chun Ta Liao,Chun Ta Liao,Hung-Ming Wang,Hung-Ming Wang,Tzu Chen Yen,Tzu Chen Yen,Ching Chi Chiu,Ya Ching Lu,Hsiao Fang Li,Ann-Joy Cheng +12 more
TL;DR: The molecular and cellular aspects of HNC carcinogenesis in Taiwan, an endemic betel quid chewing area, are discussed, which may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics.
References
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Journal ArticleDOI
Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors
TL;DR: A status report summarizing their reactions, substrates, Inducers, and Inhibitors is given in this article, with a focus on human CYtochrome P450 enzymes.
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Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues
Yoshiyuki Kuchino,F Mori,Hiroshi Kasai,Hideo Inoue,Shigenori Iwai,Kazunobu Miura,Eiko Ohtsuka,Susumu Nishimura +7 more
TL;DR: The syn-thetic oligodeoxynucleotides, with or without an 8-OH-dG residue in a specified position, were chemically synthesized and used as templates for DNA synthesis under the conditions of the dideoxy chain termination sequencing method.
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Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis
Bruce N. Ames,Lois Swirsky Gold +1 more
TL;DR: In the Perspective "Too many rodent carcinogens: Mitogenesis increases mutagenesis" by Bruce N. Ames and Lois Swirsky Gold, the last paragraph on page 970 (continuing on page 971) was incorrectly printed.
Journal Article
Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck.
Georgette Chan,Jay O. Boyle,Eun K. Yang,Fan Zhang,Peter G. Sacks,Jatin P. Shah,David R. Edelstein,Robert A. Soslow,Alane T. Koki,Bryan M. Woerner,Jaime L. Masferrer,Andrew J. Dannenberg +11 more
TL;DR: Results suggest that COX-2 may be a target for the prevention or treatment of HNSCC.
Journal ArticleDOI
Keratinocytes as initiators of inflammation
Jonathan N.W.N. Barker,Christopher E.M. Griffiths,Brian J. Nickoloff,R. S. Mitra,Vishva M. Dixit +4 more
TL;DR: The direct activation of keratinocytes, with their ability to produce the complete repertoire of pro-inflammatory cytokines, can profoundly influence endogenous and recruited immunocompetent cells, thereby providing the critical trigger responsible for the swift and clinically dramatic alterations that occur following contact between the epidermis and a host of "noxious" agents.