Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
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Functional Genetic Variant of Long Pentraxin 3 Gene Is Associated With Clinical Aspects of Oral Cancer in Male Patients
Chia-Ming Yeh,Chiao-Wen Lin,Chun-Yi Chuang,Yu-Fan Liu,Chia-Hsuan Chou,Shun-Fa Yang,Mu-Kuan Chen +6 more
TL;DR: It is suggested that PTX3 rs3816527 plays a role in oral cancer development and was correlated with the development of late-stage cancer (odds ratio], 2.328; 95% confidence interval [CI], 1.078–5.027).
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Prevalence of Head and Neck Cancer in the State of Meghalaya: Hospital-based Study
TL;DR: A 5 years retrospective study of cancer patients from 2007 to 2011 who have been registered in Civil Hospital, Shillong to quantify the spectrum of head and neck cancer (HNC) in the region hoping that this paper will help the health professionals to understand the burden of HNC in the area so as to generate strategies for future planning.
Journal ArticleDOI
Arecoline N-oxide initiates oral carcinogenesis and arecoline N-oxide mercapturic acid attenuates the cancer risk.
Srinivasan Nithiyanantham,Sankar Arumugam,Hui-Ting Hsu,Chia Min Chung,Chi-Pin Lee,Ming Hsui Tsai,Kun-Tu Yeh,Shun-Yuan Luo,Ying-Chin Ko +8 more
TL;DR: In this article, the authors estimate the oral squamous cell carcinoma inductive activity between arecoline metabolites in human cancer specimens/OSCC cells using LC-MS/MS.
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Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways.
Zi Han Tian,Jueng Tsueng Weng,Li Jane Shih,An Ci Siao,Tsai Yun Chan,Yi Wei Tsuei,Yow Chii Kuo,Tsu Shing Wang,Yung Hsi Kao +8 more
TL;DR: The results suggested that arecoline selectively affected a particular CDK subfamily, and the effects of are coline on preadipocyte growth may be related to the mechanism underlying the modulatory effect ofArecoline on body weight.
Journal ArticleDOI
Betel Nut Arecoline Induces Different Phases of Growth Arrest between Normal and Cancerous Prostate Cells through the Reactive Oxygen Species Pathway
Li Jane Shih,Li Jane Shih,Jia Yu Wang,Jing Yao Jheng,An Ci Siao,Yen Yue Lin,Yen Yue Lin,Yi Wei Tsuei,Yow Chii Kuo,Chih Pin Chuu,Yung Hsi Kao +10 more
TL;DR: Arecoline oxidant exerts differential effects on the cell cycle through modulations of regulatory proteins, and the antioxidant N-acetylcysteine blocked the arecoline-induced increase in reactive oxygen species production, decreased cell viability, altered thecell cycle, and changed the cell Cycle regulatory protein levels.
References
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Apoptosis in cancer
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