Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
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Journal ArticleDOI
Carcinogenic Effects of Areca Nut and Its Metabolites: A Review of the Experimental Evidence
Kalpani Senevirathna,Roshan Pradeep,Yovanthi Anurangi Jayasinghe,Shalindu Malshan Jayawickrama,Rasika P. Illeperuma,Saman Warnakulasuriya,Ruwan Duminda Jayasinghe +6 more
TL;DR: A review of the available evidence on the carcinogenicity of AN based on the findings reported in the recently published experimental studies is discussed in the present review as mentioned in this paper , which includes cellular and molecular effects induced by AN, including promoting epithelial-mesenchymal transition, autophagy initiation, tissue hypoxia, genotoxicity, cytotoxicity and cell death.
Journal ArticleDOI
Why do Only Certain Cases of Oral Submucous Fibrosis Undergo Malignant Transformation
Monal Yuwanati,Sachin C Sarode,Amol R. Gadbail,Shailesh Gondivkar,Gargi S Sarode,Shankargouda Patil +5 more
TL;DR: Oral submucous fibrosis (OSMF) causes desmoplasia and rigidity of the oral cavity, resulting in reduced mouth opening, and in advanced stage causes difficulty in swallowing as discussed by the authors.
Dissertation
Estimation of Salivary Immunoglobulins and Acute Phase Proteins in Patients with Potentially Malignant Disorders, Oral Cancer and Treated Oral Cancer
TL;DR: A positive correlation between smoking, chewing, alcohol consumption and development of precancer and cancer has been established and Elevated levels of salivary IgA, IgG, CRP and Haptoglobin were observed in patients with potentially malignant disorders.
Carcinogenicity test of two unsaturated derivatives of N-nitrosopiperidine in Sprague--Dawley rats
W. Lijinsky,H.W. Taylor +1 more
TL;DR: In this paper, two unsaturated derivatives of N-nitrosopiperidine (NP), n-nitroso-1,2,3,6-tetrahydropyridine (NTP) and Nnitrosoguvacoline (NGC) were administered to Sprague-Dawley rats as solutions in drinking water at concentrations equimolar (0.88 x 10/sup -3/M) with those used to test NP.
Dissertation
Pharmacological investigation of clinically achievable concentrations of resveratrol in colorectal cancer
TL;DR: The author revealed that mice as in vivo model for colon carcinogenesis and colon adenoma development, as well as preclinical models of colorectal carcinogenesis, and Resveratrol, provided new insights into cancer and life style.
References
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
TL;DR: DCMP and dAMP are incorporated selectively opposite 8-oxodG with transient inhibition of chain extension occurring 3' to the modified base, and the potentially mutagenic insertion of dAMP is targeted exclusively to the site of the lesion.
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Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
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Apoptosis in cancer
Scott W. Lowe,Athena W. Lin +1 more
TL;DR: An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
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Free radicals as mediators of tissue injury and disease.
TL;DR: This review discusses cellular sources of various radical species and their reactions with vital cellular constituents to provide insights into the controversy over whether free radicals are important mediators of tissue injury.