Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
Citations
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Journal ArticleDOI
The enigmatic epidemiology of nasopharyngeal carcinoma.
Ellen T. Chang,Hans-Olov Adami +1 more
TL;DR: There is a clear need for large-scale, population-based molecular epidemiologic studies to elucidate how environmental, viral, and genetic factors interact in both the development and the prevention of this disease.
Journal ArticleDOI
Oral submucous fibrosis: review on aetiology and pathogenesis.
Wanninayake Mudiyanselage Tilakaratne,M.F. Klinikowski,Takashi Saku,Tim J Peters,Saman Warnakulasuriya +4 more
TL;DR: Current evidence implicates collagen-related genes in the susceptibility and pathogenesis of OSF and the individual mechanisms operating at various stages of the disease-initial, intermediate and advanced need further study in order to propose appropriate therapeutic interventions.
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Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms
TL;DR: Evidence that strongly supports causative mechanisms for genotoxicity and carcinogenicity of these substitute products, including gutkha and pan masala, are strongly implicated in the recent increase in the incidence of oral submucous fibrosis is reviewed.
Journal ArticleDOI
Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men
Ariana Znaor,Paul Brennan,Vendhan Gajalakshmi,Aleyamma Mathew,Viswanathan Shanta,C Varghese,Paolo Boffetta +6 more
TL;DR: A significant dose‐response relationship for duration and amount of consumption of the 3 habits with the development of the above 3 neoplasms was observed and significant decreases in risks for all 3 cancer sites were observed in subjects who quit smoking even among those who had quit smoking 2–4 years before the interview.
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Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
Yin Ju Chen,Joseph Tung-Chieh Chang,Joseph Tung-Chieh Chang,Chun Ta Liao,Chun Ta Liao,Hung-Ming Wang,Hung-Ming Wang,Tzu Chen Yen,Tzu Chen Yen,Ching Chi Chiu,Ya Ching Lu,Hsiao Fang Li,Ann-Joy Cheng +12 more
TL;DR: The molecular and cellular aspects of HNC carcinogenesis in Taiwan, an endemic betel quid chewing area, are discussed, which may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics.
References
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Journal ArticleDOI
In vitro production of interleukin-6 by human gingival, normal buccal mucosa, and oral submucous fibrosis fibroblasts treated with betel-nut alkaloids.
TL;DR: Findings suggests that arecoline and arecaidine can enhance cell proliferation and affect fibroblasts to synthesize IL-6, and may be a contributing molecular factor in the pathological features noted in OSF.
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Zinc and iron as bioindicators of precancerous nature of oral submucous fibrosis.
TL;DR: In this article, the authors tried to ascertain bioinorganic parameters as alternate indicators of malignant potential of oral submucous fibrosis along with other clinicopathological attributes.
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Tumorigenicity study in Syrian hamsters fed areca nut together with nitrite.
TL;DR: Exposure to nitrite together with areca nut constituents appears to enhance the risk of developing malignancies in Syrian hamsters, with a statistically significant increase in malignant lymphomas in the males.
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Effect of arecanut, a masticatory, on hepatic drug metabolizing enzymes SH content and lipid peroxidation in lactating mothers and their suckling neonates
Anjali Singh,A.R. Rao +1 more
TL;DR: The changes elicited by arecanut intake in the levels/activities of enzymes of the biotransformation system, MDA level and -SH content may enhance the susceptibility of neonatal stages of mice to the action of chemical carcinogens.