Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
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TLDR
It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.About:
This article is published in Oral Oncology.The article was published on 2001-09-01. It has received 382 citations till now. The article focuses on the topics: Oral submucous fibrosis & Areca.read more
Citations
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The enigmatic epidemiology of nasopharyngeal carcinoma.
Ellen T. Chang,Hans-Olov Adami +1 more
TL;DR: There is a clear need for large-scale, population-based molecular epidemiologic studies to elucidate how environmental, viral, and genetic factors interact in both the development and the prevention of this disease.
Journal ArticleDOI
Oral submucous fibrosis: review on aetiology and pathogenesis.
Wanninayake Mudiyanselage Tilakaratne,M.F. Klinikowski,Takashi Saku,Tim J Peters,Saman Warnakulasuriya +4 more
TL;DR: Current evidence implicates collagen-related genes in the susceptibility and pathogenesis of OSF and the individual mechanisms operating at various stages of the disease-initial, intermediate and advanced need further study in order to propose appropriate therapeutic interventions.
Journal ArticleDOI
Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms
TL;DR: Evidence that strongly supports causative mechanisms for genotoxicity and carcinogenicity of these substitute products, including gutkha and pan masala, are strongly implicated in the recent increase in the incidence of oral submucous fibrosis is reviewed.
Journal ArticleDOI
Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men
Ariana Znaor,Paul Brennan,Vendhan Gajalakshmi,Aleyamma Mathew,Viswanathan Shanta,C Varghese,Paolo Boffetta +6 more
TL;DR: A significant dose‐response relationship for duration and amount of consumption of the 3 habits with the development of the above 3 neoplasms was observed and significant decreases in risks for all 3 cancer sites were observed in subjects who quit smoking even among those who had quit smoking 2–4 years before the interview.
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Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
Yin Ju Chen,Joseph Tung-Chieh Chang,Joseph Tung-Chieh Chang,Chun Ta Liao,Chun Ta Liao,Hung-Ming Wang,Hung-Ming Wang,Tzu Chen Yen,Tzu Chen Yen,Ching Chi Chiu,Ya Ching Lu,Hsiao Fang Li,Ann-Joy Cheng +12 more
TL;DR: The molecular and cellular aspects of HNC carcinogenesis in Taiwan, an endemic betel quid chewing area, are discussed, which may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics.
References
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Journal ArticleDOI
Tobacco-specific and betel nut-specific N-nitroso compounds: occurrence in saliva and urine of betel quid chewers and formation in vitro by nitrosation of betel quid
TL;DR: The results indicate that N-nitroso compounds could easily be formed in vivo in the oral cavity during chewing or in the stomach after swallowing the quids, and the levels of N- Nitrosamines and alkaloids in betel quid extracts were determined before and after nitrosation at pH 7.1.
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Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids
TL;DR: Fibroblasts are responsive to the major metabolite of arecoline and hydrolysis of the ester group may be necessary for this action, which may contribute to the accumulation of collagen in OSF.
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Mechanism-Based Cancer Prevention Approaches: Targets, Examples, and the Use of Transgenic Mice
TL;DR: The utility for mechanism-based cancer prevention research of new animal models that are based on the overexpression or inactivation of specific cancer-related genes is examined and the purposes of this review are examined.
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Micronuclei in exfoliated human cells as a tool for studies in cancer risk and cancer intervention.
H.F. Stich,M.P. Rosin +1 more
TL;DR: The micronucleus test on exfoliated cells has been successfully used to recognize population groups at an elevated risk for cancer of the oral cavity or urinary bladder and pinpoint the site within an organ from which most carcinomas will develop.