Journal ArticleDOI
Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
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TLDR
The driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes is critically assessed.About:
This article is published in Gastroenterology.The article was published on 2017-05-01. It has received 294 citations till now. The article focuses on the topics: Gut flora & Disease.read more
Citations
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Ambient temperature structures the gut microbiota of zebrafish to impact the response to radioactive pollution
TL;DR: In this paper , the effects of a temperature profile on their radiosensitivity (exposure to 20 Gy of gamma rays) was investigated to identify the potential biochemical mechanism responsible for influencing radiosensitivity, and suggest that maintaining the stability of gram-positive bacteria may be efficacious to protect aquatic organisms against short or longterm radioactive contamination in the context of global climate change.
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Multi-Omics Association Reveals the Effects of Intestinal Microbiome–Host Interactions on Fat Deposition in Broilers
Yang Jing,Yuqi Yuan,Melissa S. Monson,Peng Wang,Fang Mu,Qi Zhang,Wei Na,Ke Zhang,Yuxiang Wang,Li Leng,Yumao Li,Peng Luan,Ning Wang,Rong Jun Guo,Susan J. Lamont,Hui Li,Hui Yuan +16 more
TL;DR: Multi-omics associations suggest that abdominal fat deposition may be influenced by the interactions of specific gut microbiota abundance and the expression of host genes in the intestinal compartments in which the microbes reside.
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Gut microbial differences in breast and prostate cancer cases from two randomised controlled trials compared to matched cancer-free controls.
Kristen S Smith,Andrew D. Frugé,W. Van Der Pol,N E Caston,Casey D. Morrow,Wendy Demark-Wahnefried,Tiffany L. Carson +6 more
TL;DR: In this article, the faecal microbiota of newly diagnosed treatment-naive overweight and obese cancer patients and matched controls were compared using the QIIME pipeline, showing significant differences among 16 genera in all matches.
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Rectal swabs are a reliable method of assessing the colonic microbiome.
Greg A. Turner,Michael J. O'Grady,Danielle Hudson,Xochitl C. Morgan,Frank A. Frizelle,Rachel V. Purcell +5 more
TL;DR: In this article , the authors evaluated the use of rectal swabs compared to faecal specimens for colonic microbiome analysis and found that the rectal sample type accounted for only 6.8% of community variation (R2 = 0.067, p < 0.001).
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Different gut microbiome composition in obese Guizhou minipigs between female and castrated male.
TL;DR: It is suggested that the castrated male has different gut microbial composition compared to the obese female and the influence of gut microbiome on obesity between them is different, and the main adipogenic gut microorganism in obese Guizhou minipigs in the authors' studies is the same with that in other obese mammals.
References
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Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
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A core gut microbiome in obese and lean twins
Peter J. Turnbaugh,Micah Hamady,Tanya Yatsunenko,Brandi L. Cantarel,Alexis E. Duncan,Ruth E. Ley,Mitchell L. Sogin,William J. Jones,Bruce A. Roe,Jason P. Affourtit,Michael Egholm,Bernard Henrissat,Andrew C. Heath,Rob Knight,Jeffrey I. Gordon +14 more
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
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Human gut microbiome viewed across age and geography
Tanya Yatsunenko,Federico E. Rey,Mark J. Manary,Mark J. Manary,Indi Trehan,Indi Trehan,Maria Gloria Dominguez-Bello,Monica Contreras,Magda Magris,Glida Hidalgo,Robert N. Baldassano,Andrey P. Anokhin,Andrew C. Heath,Barbara B. Warner,Jens Reeder,Justin Kuczynski,J. Gregory Caporaso,Catherine A. Lozupone,Christian L. Lauber,Jose C. Clemente,Dan Knights,Rob Knight,Jeffrey I. Gordon +22 more
TL;DR: The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood.
Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.