Journal ArticleDOI
Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
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TLDR
The driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes is critically assessed.About:
This article is published in Gastroenterology.The article was published on 2017-05-01. It has received 294 citations till now. The article focuses on the topics: Gut flora & Disease.read more
Citations
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Journal ArticleDOI
Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives
TL;DR: More randomized controlled trials and larger prospective studies including well-defined cohorts as well as a multi-omics approach are warranted to better identify the associations between the gut microbiome, microbial metabolites, and obesity and its metabolic complications.
Journal ArticleDOI
Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites
Shiho Fujisaka,Shiho Fujisaka,Julian Avila-Pacheco,Marion Soto,Aleksandar Kostic,Jonathan M. Dreyfuss,Jonathan M. Dreyfuss,Hui Pan,Hui Pan,Siegfried Ussar,Emrah Altindis,Ning Li,Lynn Bry,Clary B. Clish,C. Ronald Kahn +14 more
TL;DR: Cecal and plasma metabolites showed multifold differences reflecting the combined and integrated effects of diet, antibiotics, host background, and the gut microbiome, which can contribute to regulation of metabolism and insulin resistance.
Journal ArticleDOI
Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder.
TL;DR: A systematic review of clinical studies of microbiome in schizophrenia and bipolar disorder suggests that these disorders are associated with reduced microbial diversity and show global community differences compared to non-psychiatric comparison samples.
Journal ArticleDOI
Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses
Zhilei Shan,Yanping Li,Geng Zong,Yanjun Guo,Yanjun Guo,Jun Li,JoAnn E. Manson,JoAnn E. Manson,Frank B. Hu,Frank B. Hu,Walter C. Willett,Walter C. Willett,Eva S. Schernhammer,Eva S. Schernhammer,Eva S. Schernhammer,Shilpa N Bhupathiraju,Shilpa N Bhupathiraju +16 more
TL;DR: It is suggested that most cases of type 2 diabetes could be prevented by adhering to a healthy lifestyle, and the benefits could be greater in rotating night shift workers.
Journal ArticleDOI
Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects
Tanya T. Nguyen,Tomasz Kosciolek,Yadira Maldonado,Rebecca Daly,Averria Sirkin Martin,Daniel McDonald,Rob Knight,Dilip V. Jeste +7 more
TL;DR: Evidence of altered gut microbial composition in persons with chronic schizophrenia is provided and a need for larger and longitudinal studies of microbiome in schizophrenia is suggested.
References
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Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
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A core gut microbiome in obese and lean twins
Peter J. Turnbaugh,Micah Hamady,Tanya Yatsunenko,Brandi L. Cantarel,Alexis E. Duncan,Ruth E. Ley,Mitchell L. Sogin,William J. Jones,Bruce A. Roe,Jason P. Affourtit,Michael Egholm,Bernard Henrissat,Andrew C. Heath,Rob Knight,Jeffrey I. Gordon +14 more
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI
Human gut microbiome viewed across age and geography
Tanya Yatsunenko,Federico E. Rey,Mark J. Manary,Mark J. Manary,Indi Trehan,Indi Trehan,Maria Gloria Dominguez-Bello,Monica Contreras,Magda Magris,Glida Hidalgo,Robert N. Baldassano,Andrey P. Anokhin,Andrew C. Heath,Barbara B. Warner,Jens Reeder,Justin Kuczynski,J. Gregory Caporaso,Catherine A. Lozupone,Christian L. Lauber,Jose C. Clemente,Dan Knights,Rob Knight,Jeffrey I. Gordon +22 more
TL;DR: The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood.
Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.