Journal ArticleDOI
Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
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TLDR
The driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes is critically assessed.About:
This article is published in Gastroenterology.The article was published on 2017-05-01. It has received 294 citations till now. The article focuses on the topics: Gut flora & Disease.read more
Citations
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Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance
Nicola Wilck,Johannes Holle +1 more
TL;DR: In this article , the authors analyzed the fecal microbiome, metabolites, and immune phenotypes in 48 children (with normal kidney function, CKD stage G3-G4, G5 treated by hemodialysis [HD], or kidney transplantation) with a mean±SD age of 10.6±3.8 years.
Journal ArticleDOI
Changes in the Mucosa-Associated Microbiome and Transcriptome across Gut Segments Are Associated with Obesity in a Metabolic Syndrome Porcine Model
Song-Song Xu,Nianshuang Wang,Lei Huang,Xiu-ling Zhang,Shutang Feng,Shan Liu,Yue Wang,Zhiguo Liu,Bing-Yuan Wang,Tianwen Wu,Yulian Mu,Shao-Hua Hou,Kui Li +12 more
TL;DR: Dysbiosis of mucosal microbiota along the entire digestive tract play a critical role in the proinflammatory response in the host-microbial metabolism axis, resulting in obesity and related metabolic disorders in the MetS model.
Journal ArticleDOI
Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome
Jonathan B. Jacobs,Maryam Goudarzi,Venu Lagishetty,Dalin Li,Tytus D. Mak,Maomeng Tong,Paul M. Ruegger,Talin Haritunians,Carol J. Landers,Phillip Fleshner,Eric A. Vasiliauskas,Andrew Ippoliti,Gil Y. Melmed,David Q. Shih,Stephan R. Targan,James Borneman,Albert J. Fornace,Dermot P.B. McGovern,Jonathan Braun +18 more
TL;DR: In this article , the authors used lavage sampling to characterize the colonic mucosal-luminal interface (MLI) microbiome of Crohn's disease patients in endoscopic remission and unaffected controls relative to obesity, disease genetics, and phenotype.
Journal ArticleDOI
Effects of Chronic Exposure to Microcystin-LR on the Gut Microbiota of Male Mice.
TL;DR: The results showed that significant changes of species diversity were observed in the gut microbiota of MC-LR-exposed mice, and comparative analysis of the microbial communities showed that the reduction of the Actinobacteria and Saccharibacteria populations was detected in MC- LR-exp exposed mice.
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Dose-response association of early-life antibiotic exposure and subsequent overweight or obesity in children: A meta-analysis of prospective studies
Xin Meng,Yi Zhu,Hongkun Di,Mingye Zhang,Jing Feng,Minzhi Xu,Wenqi Xia,Qingfeng Tian,Yan He,Yong Gan,Zuxun Lu +10 more
TL;DR: In this paper, the authors investigated the dose-response relationship between antibiotic exposure in early life and the risk of subsequent overweight or obesity and found that there was a logarithmic-curve relationship between early-life antibiotic exposure and subsequent overweight and obesity.
References
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Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI
A core gut microbiome in obese and lean twins
Peter J. Turnbaugh,Micah Hamady,Tanya Yatsunenko,Brandi L. Cantarel,Alexis E. Duncan,Ruth E. Ley,Mitchell L. Sogin,William J. Jones,Bruce A. Roe,Jason P. Affourtit,Michael Egholm,Bernard Henrissat,Andrew C. Heath,Rob Knight,Jeffrey I. Gordon +14 more
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI
Human gut microbiome viewed across age and geography
Tanya Yatsunenko,Federico E. Rey,Mark J. Manary,Mark J. Manary,Indi Trehan,Indi Trehan,Maria Gloria Dominguez-Bello,Monica Contreras,Magda Magris,Glida Hidalgo,Robert N. Baldassano,Andrey P. Anokhin,Andrew C. Heath,Barbara B. Warner,Jens Reeder,Justin Kuczynski,J. Gregory Caporaso,Catherine A. Lozupone,Christian L. Lauber,Jose C. Clemente,Dan Knights,Rob Knight,Jeffrey I. Gordon +22 more
TL;DR: The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood.
Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.