Journal ArticleDOI
Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
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TLDR
The driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes is critically assessed.About:
This article is published in Gastroenterology.The article was published on 2017-05-01. It has received 294 citations till now. The article focuses on the topics: Gut flora & Disease.read more
Citations
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Regional variation limits applications of healthy gut microbiome reference ranges and disease models.
Yan He,Wei Wu,Wei Wu,Hui-Min Zheng,Pan Li,Daniel McDonald,Hua-Fang Sheng,Mu-Xuan Chen,Zihui Chen,Guiyuan Ji,Zhong-Dai-Xi Zheng,Prabhakar Mujagond,Xiaojiao Chen,Zu-Hua Rong,Peng Chen,Li-Yi Lyu,Xian Wang,Chong-Bin Wu,Nan Yu,Yanjun Xu,Jia Yin,Jeroen Raes,Jeroen Raes,Rob Knight,Wenjun Ma,Hongwei Zhou +25 more
TL;DR: To understand the generalizability of microbiota-based diagnostic models of metabolic disease, the gut microbiota was characterized of 7,009 individuals from 14 districts within 1 province in China and among phenotypes, host location showed the strongest associations with microbiota variations.
Journal ArticleDOI
Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography.
Mélanie Deschasaux,Kristien E. C. Bouter,Andrei Prodan,Evgeni Levin,Albert K. Groen,Hilde Herrema,Valentina Tremaroli,Guido J. Bakker,Ilias Attaye,Sara-Joan Pinto-Sietsma,Daniël H. van Raalte,Marieke B. Snijder,Mary Nicolaou,Ron J.G. Peters,Aeilko H. Zwinderman,Fredrik Bäckhed,Fredrik Bäckhed,Max Nieuwdorp,Max Nieuwdorp +18 more
TL;DR: Stool microbiota composition correlates with the ethnic backgrounds of people living in the same city, suggesting that geographical location and ethnicity have distinct effects on microbiota.
Journal ArticleDOI
Metabolically healthy obesity: facts and fantasies.
TL;DR: The definition, stability over time, and clinical outcomes of MHO are reviewed, and the potential factors that could explain differences in metabolic health in people with MHO and MUO are discussed - specifically, modifiable lifestyle factors and adipose tissue biology.
Journal ArticleDOI
Probiotics, prebiotics, synbiotics and insulin sensitivity
TL;DR: The aim of the present review was to investigate the effects of probiotics, prebiotics and synbiotics (a combination of probiotic and prebiotic) on insulin resistance in human clinical trials and to discuss the potential mechanisms whereby probiotics and pre biotics improve glucose metabolism.
Journal ArticleDOI
Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention
Yan Liu,Yao Wang,Yueqiong Ni,Yueqiong Ni,Cynthia K Y Cheung,Karen S.L. Lam,Yu Wang,Zhengyuan Xia,Dewei Ye,Jiao Guo,Michael Andrew Tse,Gianni Panagiotou,Gianni Panagiotou,Gianni Panagiotou,Aimin Xu +14 more
TL;DR: It is found that exercise-induced alterations in the gut microbiota correlated closely with improvements in glucose homeostasis and insulin sensitivity and raised the possibility of maximizing the benefits of exercise by targeting the Gut microbiota.
References
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Journal ArticleDOI
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
Kristoffer Forslund,Falk Hildebrand,Falk Hildebrand,Trine Nielsen,Gwen Falony,Gwen Falony,Shinichi Sunagawa,Edi Prifti,Sara Vieira-Silva,Sara Vieira-Silva,Valborg Gudmundsdottir,Helle Krogh Pedersen,Manimozhiyan Arumugam,Karsten Kristiansen,Anita Y. Voigt,Anita Y. Voigt,Henrik Vestergaard,Rajna Hercog,Paul I. Costea,Jens Roat Kultima,Junhua Li,Torben Jørgensen,Torben Jørgensen,Florence Levenez,Joël Doré,H. Bjørn Nielsen,Søren Brunak,Søren Brunak,Jeroen Raes,Jeroen Raes,Jeroen Raes,Torben Hansen,Torben Hansen,Jun Wang,S. Dusko Ehrlich,S. Dusko Ehrlich,Peer Bork,Oluf Pedersen +37 more
TL;DR: A unified signature of gut microbiome shifts in T2D with a depletion of butyrate-producing taxa is reported, highlighting the need to disentangle gut microbiota signatures of specific human diseases from those of medication.
Journal ArticleDOI
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Benoit Chassaing,Omry Koren,Julia K. Goodrich,Angela C. Poole,Shanthi Srinivasan,Ruth E. Ley,Andrew T. Gewirtz +6 more
TL;DR: Results support the emerging concept that perturbed host–microbiota interactions resulting in low-grade inflammation can promote adiposity and its associated metabolic effects and suggest that the broad use of emulsifying agents might be contributing to an increased societal incidence of obesity/metabolic syndrome and other chronic inflammatory diseases.
Journal ArticleDOI
Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans
Ron Sender,Shai Fuchs,Ron Milo +2 more
TL;DR: It is often presented as common knowledge that bacteria outnumber human cells by a ratio of at least 10:1, but it is found that the ratio is much closer to 1:1.
Journal ArticleDOI
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
Alexandra Zhernakova,Alexander Kurilshikov,Marc Jan Bonder,Ettje F. Tigchelaar,Melanie Schirmer,Tommi Vatanen,Zlatan Mujagic,Arnau Vich Vila,Gwen Falony,Sara Vieira-Silva,Sara Vieira-Silva,Jun Wang,Jun Wang,Floris Imhann,Eelke Brandsma,Soesma A Jankipersadsing,Marie Joossens,María Carmen Cenit,Patrick Deelen,Morris A. Swertz,Rinse K. Weersma,Edith J. M. Feskens,Mihai G. Netea,Dirk Gevers,Daisy Jonkers,Lude Franke,Yurii S. Aulchenko,Curtis Huttenhower,Curtis Huttenhower,Jeroen Raes,Jeroen Raes,Jeroen Raes,Marten H. Hofker,Ramnik J. Xavier,Cisca Wijmenga,Jingyuan Fu +35 more
TL;DR: Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors, and an important step toward a better understanding of environment-diet-microbe-host interactions.
Journal ArticleDOI
A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
Hubert Plovier,Amandine Everard,Céline Druart,Clara Depommier,Matthias Van Hul,Lucie Geurts,Julien Chilloux,Noora Ottman,Thibaut Duparc,Laeticia Lichtenstein,Antonis Myridakis,Nathalie M. Delzenne,Judith Klievink,Arnab Bhattacharjee,Kees C. H. van der Ark,Steven Aalvink,Laurent O. Martinez,Marc-Emmanuel Dumas,Dominique Maiter,Audrey Loumaye,Michel P. Hermans,Jean-Paul Thissen,Clara Belzer,Willem M. de Vos,Willem M. de Vos,Patrice D. Cani +25 more
TL;DR: It is shown that A. muciniphila retains its efficacy when grown on a synthetic medium compatible with human administration and enhanced its capacity to reduce fat mass development, insulin resistance and dyslipidemia in mice, and Amuc_1100, a specific protein isolated from the outer membrane of A. Sydneyi, interacts with Toll-like receptor 2, is stable at temperatures used for pasteurization and partly recapitulates the beneficial effects of the bacterium.