Journal ArticleDOI
Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
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TLDR
The driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes is critically assessed.About:
This article is published in Gastroenterology.The article was published on 2017-05-01. It has received 294 citations till now. The article focuses on the topics: Gut flora & Disease.read more
Citations
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Journal ArticleDOI
Regional variation limits applications of healthy gut microbiome reference ranges and disease models.
Yan He,Wei Wu,Wei Wu,Hui-Min Zheng,Pan Li,Daniel McDonald,Hua-Fang Sheng,Mu-Xuan Chen,Zihui Chen,Guiyuan Ji,Zhong-Dai-Xi Zheng,Prabhakar Mujagond,Xiaojiao Chen,Zu-Hua Rong,Peng Chen,Li-Yi Lyu,Xian Wang,Chong-Bin Wu,Nan Yu,Yanjun Xu,Jia Yin,Jeroen Raes,Jeroen Raes,Rob Knight,Wenjun Ma,Hongwei Zhou +25 more
TL;DR: To understand the generalizability of microbiota-based diagnostic models of metabolic disease, the gut microbiota was characterized of 7,009 individuals from 14 districts within 1 province in China and among phenotypes, host location showed the strongest associations with microbiota variations.
Journal ArticleDOI
Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography.
Mélanie Deschasaux,Kristien E. C. Bouter,Andrei Prodan,Evgeni Levin,Albert K. Groen,Hilde Herrema,Valentina Tremaroli,Guido J. Bakker,Ilias Attaye,Sara-Joan Pinto-Sietsma,Daniël H. van Raalte,Marieke B. Snijder,Mary Nicolaou,Ron J.G. Peters,Aeilko H. Zwinderman,Fredrik Bäckhed,Fredrik Bäckhed,Max Nieuwdorp,Max Nieuwdorp +18 more
TL;DR: Stool microbiota composition correlates with the ethnic backgrounds of people living in the same city, suggesting that geographical location and ethnicity have distinct effects on microbiota.
Journal ArticleDOI
Metabolically healthy obesity: facts and fantasies.
TL;DR: The definition, stability over time, and clinical outcomes of MHO are reviewed, and the potential factors that could explain differences in metabolic health in people with MHO and MUO are discussed - specifically, modifiable lifestyle factors and adipose tissue biology.
Journal ArticleDOI
Probiotics, prebiotics, synbiotics and insulin sensitivity
TL;DR: The aim of the present review was to investigate the effects of probiotics, prebiotics and synbiotics (a combination of probiotic and prebiotic) on insulin resistance in human clinical trials and to discuss the potential mechanisms whereby probiotics and pre biotics improve glucose metabolism.
Journal ArticleDOI
Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention
Yan Liu,Yao Wang,Yueqiong Ni,Yueqiong Ni,Cynthia K Y Cheung,Karen S.L. Lam,Yu Wang,Zhengyuan Xia,Dewei Ye,Jiao Guo,Michael Andrew Tse,Gianni Panagiotou,Gianni Panagiotou,Gianni Panagiotou,Aimin Xu +14 more
TL;DR: It is found that exercise-induced alterations in the gut microbiota correlated closely with improvements in glucose homeostasis and insulin sensitivity and raised the possibility of maximizing the benefits of exercise by targeting the Gut microbiota.
References
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Journal ArticleDOI
An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk
Nissan Yissachar,Yan Zhou,Lloyd W. Ung,Nicole Y. Lai,James F. Mohan,Allen J. Ehrlicher,David A. Weitz,Dennis L. Kasper,Isaac M. Chiu,Diane Mathis,Christophe Benoist +10 more
TL;DR: Differential engagement of the enteric nervous system may partake in bifurcating pro- or anti-inflammatory responses to microbes, as demonstrated by activation of sensory neurons by microbes, correlating with RORg+ Treg induction.
Journal ArticleDOI
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
Charles R. Flynn,Vance L. Albaugh,Steven Cai,Joyce Cheung-Flynn,Phillip E. Williams,Robert M. Brucker,Seth R. Bordenstein,Yan Guo,David H. Wasserman,Naji N. Abumrad +9 more
TL;DR: Bile diversion, independent of surgical rearrangement of the gastrointestinal tract, imparts significant weight loss accompanied by improved glucose and lipid homeostasis that are hallmarks of RYGB.
Journal ArticleDOI
Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance
Emmanuel Denou,Karine Lolmède,Karine Lolmède,Lucile Garidou,Lucile Garidou,Céline Pomié,Céline Pomié,Chantal Chabo,Chantal Chabo,Trevor C. Lau,Morgan D. Fullerton,Giulia Nigro,Alexia Zakaroff-Girard,Alexia Zakaroff-Girard,Elodie Luche,Elodie Luche,Céline Garret,Céline Garret,Matteo Serino,Matteo Serino,Jacques Amar,Jacques Amar,Michael Courtney,Joseph F. Cavallari,Brandyn D. Henriksbo,Nicole G. Barra,Kevin P. Foley,Joseph B. McPhee,Brittany M. Duggan,Hayley M. O'Neill,Amanda J. Lee,Philippe J. Sansonetti,Ali A. Ashkar,Waliul I. Khan,Michael G. Surette,Anne Bouloumié,Anne Bouloumié,Gregory R. Steinberg,Rémy Burcelin,Rémy Burcelin,Jonathan D. Schertzer +40 more
TL;DR: It is demonstrated that NOD2 detection of bacterial cell wall peptidoglycan (PGN) regulates metabolic inflammation and insulin sensitivity and warrants scrutiny of bacterial component detection, dysbiosis, and protective immune responses in the links between inflammatory gut and metabolic diseases, including diabetes.
Journal ArticleDOI
Causality of small and large intestinal microbiota in weight regulation and insulin resistance
Torsten P. M. Scheithauer,Torsten P. M. Scheithauer,Geesje M. Dallinga-Thie,Willem M. de Vos,Max Nieuwdorp,Max Nieuwdorp,Daniël H. van Raalte +6 more
TL;DR: Interventions aimed to restoring gut microbial homeostasis, such as ingestion of specific fibers or therapeutic microbes, are promising strategies to reduce insulin resistance and the related metabolic abnormalities in obesity, metabolic syndrome, and type 2 diabetes.
Journal ArticleDOI
Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.
Vishal Singh,Benoit Chassaing,Limin Zhang,Limin Zhang,Beng San Yeoh,Xia Xiao,Manish Kumar,Mark T. Baker,Jingwei Cai,Rachel E Walker,Kamil Borkowski,Kevin J. Harvatine,Nagendra Singh,Gregory C. Shearer,James M. Ntambi,Bina Joe,Andrew D. Patterson,Andrew T. Gewirtz,Matam Vijay-Kumar +18 more
TL;DR: Deletion of hepatic SCD1 not only prevented hepatic neutral lipid oleate enrichment but also ameliorated metabolic syndrome in T5KO mice, underscoring the key role of the gut microbiota-liver axis in the pathogenesis of metabolic diseases.