Journal ArticleDOI
Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
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TLDR
The driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes is critically assessed.About:
This article is published in Gastroenterology.The article was published on 2017-05-01. It has received 294 citations till now. The article focuses on the topics: Gut flora & Disease.read more
Citations
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Journal ArticleDOI
Effect of Dietary Lipids on Endotoxemia Influences Postprandial Inflammatory Response
Javier Lopez-Moreno,Sonia García-Carpintero,Sonia García-Carpintero,Rosa Jimenez-Lucena,Rosa Jimenez-Lucena,Carmen Haro,Carmen Haro,Oriol A. Rangel-Zuñiga,Oriol A. Rangel-Zuñiga,Ruth Blanco-Rojo,Ruth Blanco-Rojo,Elena M. Yubero-Serrano,Elena M. Yubero-Serrano,Francisco J. Tinahones,Javier Delgado-Lista,Javier Delgado-Lista,Pablo Perez-Martinez,Pablo Perez-Martinez,Helen M. Roche,Jose Lopez-Miranda,Jose Lopez-Miranda,Antonio Camargo,Antonio Camargo +22 more
TL;DR: The results suggest that the consumption of HSFA diet increases the intestinal absorption of LPS which, in turn, increases postprandial endotoxemia levels and the postPRandial inflammatory response.
Journal ArticleDOI
Lactobacillus plantarum DR7 Modulated Bowel Movement and Gut Microbiota Associated with Dopamine and Serotonin Pathways in Stressed Adults.
TL;DR: The present data showed that physiological changes induced by L. plantarum DR7 could be associated with changes in specific taxa of the gut microbiota along the serotonin and dopamine pathways.
Journal ArticleDOI
Celastrol in metabolic diseases: Progress and application prospects.
TL;DR: In this article, a systematic review of the mechanism of action and therapeutic properties of celastrol in various metabolic diseases and complications is presented, and potential research strategies might contribute to the Celastrol's clinical application in the future.
Journal ArticleDOI
Bacterial Microbiota and Fatty Acids in the Faeces of Overweight and Obese Children.
Renata Barczynska,Mieczysław Litwin,Katarzyna Slizewska,Mieczysław Szalecki,Agnieszka Berdowska,Katarzyna Bandurska,Zdzisława Libudzisz,Janusz Kapuśniak +7 more
TL;DR: Obesity was associated with intestinal dysbiosis and a predominance of phylum Firmicutes and stool of obese children contained lower amounts of SCFAs, and differences were significant only in obese children, not in overweight children in comparison with the lean ones.
Journal ArticleDOI
Dysbiosis of intestinal microbiota induced by dietary oxidized fish oil and recovery of diet-induced dysbiosis via taurine supplementation in rice field eel (Monopterus albus)
TL;DR: The results suggested that the oxidized fish oil diet could disturb the stability of microbial community and cause microbial dysfunctions, whereas taurine supplementation helped the intestinal microbiota homeostasis and restored its function.
References
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Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI
A core gut microbiome in obese and lean twins
Peter J. Turnbaugh,Micah Hamady,Tanya Yatsunenko,Brandi L. Cantarel,Alexis E. Duncan,Ruth E. Ley,Mitchell L. Sogin,William J. Jones,Bruce A. Roe,Jason P. Affourtit,Michael Egholm,Bernard Henrissat,Andrew C. Heath,Rob Knight,Jeffrey I. Gordon +14 more
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI
Human gut microbiome viewed across age and geography
Tanya Yatsunenko,Federico E. Rey,Mark J. Manary,Mark J. Manary,Indi Trehan,Indi Trehan,Maria Gloria Dominguez-Bello,Monica Contreras,Magda Magris,Glida Hidalgo,Robert N. Baldassano,Andrey P. Anokhin,Andrew C. Heath,Barbara B. Warner,Jens Reeder,Justin Kuczynski,J. Gregory Caporaso,Catherine A. Lozupone,Christian L. Lauber,Jose C. Clemente,Dan Knights,Rob Knight,Jeffrey I. Gordon +22 more
TL;DR: The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood.
Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.