Journal ArticleDOI
Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
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TLDR
The driving role of intestinal microbe composition in the etiology, prevention, and treatment of obesity and obesity-related metabolic dysfunction, including type 2 diabetes is critically assessed.About:
This article is published in Gastroenterology.The article was published on 2017-05-01. It has received 294 citations till now. The article focuses on the topics: Gut flora & Disease.read more
Citations
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Journal ArticleDOI
Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?
Gracia M. Martin-Nuñez,Gracia M. Martin-Nuñez,Isabel Cornejo-Pareja,Isabel Cornejo-Pareja,Mercedes Clemente-Postigo,Mercedes Clemente-Postigo,Francisco J. Tinahones,Francisco J. Tinahones +7 more
TL;DR: In this paper, the role of gut microbiota as the linking factor between H. pylori infection and metabolic diseases is discussed, and the impact that gut bacterial modulation by H.pylori eradication treatment can also have in host's metabolism.
Journal ArticleDOI
Exposure to copper altered the intestinal microbiota in Chinese brown frog (Rana chensinensis).
Yijie Yang,Yijie Yang,Xiuling Song,Xiuling Song,Aixia Chen,Aixia Chen,Hongyuan Wang,Lihong Chai,Lihong Chai +8 more
TL;DR: Results indicated that total body length, intestinal wet weight, and total body wet weight were reduced in 0.75 μM CuSO4 exposure group, which provides new perspective to explore the effect of heavy metal on the intestinal health of amphibians.
Journal ArticleDOI
The canine gastrointestinal microbiota: early studies and research frontiers
TL;DR: Studying canine intestinal microorganisms enables clarifying changes in the canine intestinal bacteria under different conditions, simulating human diseases in dog models, and conducting in-depth studies of the interactions between intestinal bacteria and disease.
Journal ArticleDOI
Human gut microbiota in health and disease: Unveiling the relationship
Muhammad Afzaal,Farhan Saeed,Yasir Abbas Shah,Muzzamal Hussain,Roshina Rabail,Claudia Terezia Socol,Abdo Hassoun,Mirian Pateiro,José M. Lorenzo,Alexandru Rusu,Rana Muhammad Aadil +10 more
TL;DR: A comprehensive understanding of gut microbiota interactions, its role in health and disease, and recent updates on the subject are the striking topics of the current review.
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The gut microbiota as a versatile immunomodulator in obesity and associated metabolic disorders.
Rebeca Liébana-García,Marta Olivares,Clara Bullich-Vilarrubias,Inmaculada López-Almela,Marina Romaní-Pérez,Yolanda Sanz +5 more
TL;DR: The role of the microbiome in the regulation of intestinal and systemic immunity is discussed in this article, where the authors review the mechanisms whereby "obesogenic" diets and the microbiome impact immunity, locally and systemically.
References
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Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI
A core gut microbiome in obese and lean twins
Peter J. Turnbaugh,Micah Hamady,Tanya Yatsunenko,Brandi L. Cantarel,Alexis E. Duncan,Ruth E. Ley,Mitchell L. Sogin,William J. Jones,Bruce A. Roe,Jason P. Affourtit,Michael Egholm,Bernard Henrissat,Andrew C. Heath,Rob Knight,Jeffrey I. Gordon +14 more
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI
Human gut microbiome viewed across age and geography
Tanya Yatsunenko,Federico E. Rey,Mark J. Manary,Mark J. Manary,Indi Trehan,Indi Trehan,Maria Gloria Dominguez-Bello,Monica Contreras,Magda Magris,Glida Hidalgo,Robert N. Baldassano,Andrey P. Anokhin,Andrew C. Heath,Barbara B. Warner,Jens Reeder,Justin Kuczynski,J. Gregory Caporaso,Catherine A. Lozupone,Christian L. Lauber,Jose C. Clemente,Dan Knights,Rob Knight,Jeffrey I. Gordon +22 more
TL;DR: The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood.
Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.