Salmonella enterica Serovar Typhi Conceals the Invasion-Associated Type Three Secretion System from the Innate Immune System by Gene Regulation
Sebastian E. Winter,Maria G. Winter,Maria G. Winter,Victor Poon,A. Marijke Keestra,Torsten Sterzenbach,Franziska Faber,Luciana F. Costa,Fabiane Cassou,Érica Azevedo Costa,Geraldo Eleno Silveira Alves,Tatiane A. Paixão,Renato L. Santos,Andreas J. Bäumler +13 more
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TLDR
It is shown that Salmonella enterica serovar Typhi, the causative agent of typhoid fever, tightly regulates expression of the invasion-associated type III secretion system (T3SS-1) and thus fails to activate these innate immune signaling pathways.Abstract:
Delivery of microbial products into the mammalian cell cytosol by bacterial secretion systems is a strong stimulus for triggering pro-inflammatory host responses. Here we show that Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, tightly regulates expression of the invasion-associated type III secretion system (T3SS-1) and thus fails to activate these innate immune signaling pathways. The S. Typhi regulatory protein TviA rapidly repressed T3SS-1 expression, thereby preventing RAC1-dependent, RIP2-dependent activation of NF-κB in epithelial cells. Heterologous expression of TviA in S. enterica serovar Typhimurium (S. Typhimurium) suppressed T3SS-1-dependent inflammatory responses generated early after infection in animal models of gastroenteritis. These results suggest that S. Typhi reduces intestinal inflammation by limiting the induction of pathogen-induced processes through regulation of virulence gene expression.read more
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The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection
Lisa Del Bel Belluz,Riccardo Guidi,Ioannis S. Pateras,Laura Levi,Boris Mihaljevic,Syed Fazle Rouf,Marie Wrande,Marco Candela,Silvia Turroni,Claudia Nastasi,Clarissa Consolandi,Clelia Peano,Toma Tebaldi,Gabriella Viero,Vassilis G. Gorgoulis,Thorbjørn Krejsgaard,Mikael Rhen,Teresa Frisan +17 more
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Evolution of Salmonella within Hosts.
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Multivalent gold nanoparticle-peptide conjugates for targeting intracellular bacterial infections.
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The transcriptional regulator SsrB is involved in a molecular switch controlling virulence lifestyles of Salmonella.
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Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal Tissue.
Kourtney P. Nickerson,Stefania Senger,Y. Zhang,Renata C. Lima,S. Patel,Laura A. MacKenzie Ingano,William A. Flavahan,Deepak Kumar,Claire M. Fraser,Christina S. Faherty,Marcelo B. Sztein,Maria Fiorentino,Alessio Fasano +12 more
TL;DR: Mechanistic strategies that S. Typhi uses to rearrange the cellular machinery of the host cytoskeleton to successfully invade the intestinal epithelium, promote polarized cytokine release and evade immune system activation are shown.
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