Secretome profiling of primary human skeletal muscle cells
Sonja Hartwig,Silja Raschke,Birgit Knebel,Mika Scheler,Martin Irmler,Waltraud Passlack,Stefan Müller,Franz-Georg Hanisch,Thomas Franz,Xinping Li,Hans-Dieter Dicken,Kristin Eckardt,Johannes Beckers,Martin Hrabé de Angelis,Cora Weigert,Hans-Ulrich Häring,Hadi Al-Hasani,D. Margriet Ouwens,Jürgen Eckel,Jorg Kotzka,Stefan Lehr +20 more
Reads0
Chats0
TLDR
The present study aimed at characterizing the secretome of differentiated primary human skeletal muscle cells derived from healthy, adult donors combining three different mass spectrometry based non-targeted approaches as well as one antibody based method.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2014-05-01 and is currently open access. It has received 135 citations till now. The article focuses on the topics: Skeletal muscle & Signal peptide.read more
Citations
More filters
Journal ArticleDOI
Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
TL;DR: Evidence is provided that hepatic steatosis has a causal role in the development of insulin resistance in other tissues, such as skeletal muscle, and recent advances in the understanding of how Steatosis alters hepatokine secretion to influence metabolic phenotypes through inter-organ communication are discussed.
Journal ArticleDOI
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
TL;DR: The most recent developments in the study of muscle as an endocrine organ are summarized and the potential impact on the understanding of exercise and sedentary physiology, respectively are speculated.
Journal ArticleDOI
Adipose tissue and its role in organ crosstalk.
TL;DR: To depict the endocrine crosstalk between adipose tissue with skeletal muscle, the cardiovascular system and the pancreas, the main findings regarding the direct effects of adiponectin, leptin, DPP4 and visfatin on skeletal muscle insulin resistance, cardiovascular function and β‐cell growth and function are reported.
Journal ArticleDOI
Role of Myokines in Regulating Skeletal Muscle Mass and Function.
Jong Han Lee,Hee-Sook Jun +1 more
TL;DR: This review article summarizes the current knowledge of major identified and characterized myokines focusing on their biological activity and function, particularly in muscle mass and function.
Journal ArticleDOI
Muscle as a paracrine and endocrine organ
Jimena Giudice,Joan M. Taylor +1 more
TL;DR: Analyses of the skeletal muscle secretome revealed that numerous myokines are secreted in response to contraction or strength training, and that these factors not only regulate energy demand but also contribute to the broad beneficial effects of exercise on cardiovascular, metabolic, and mental health.
References
More filters
Journal ArticleDOI
Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
David Yaffe,Ora Saxel +1 more
TL;DR: The present report describes the isolation of a cloned population of myogenic cells, derived from adult dystrophic mouse muscle, that can proliferate and differentiate in cell culture.
Journal ArticleDOI
Muscles, exercise and obesity: skeletal muscle as a secretory organ
TL;DR: The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs, such as adipose tissue, liver, pancreas, bones and brain.
Journal ArticleDOI
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
Andrew L. Carey,Gregory R. Steinberg,S. Lance Macaulay,Walter G. Thomas,Anna G Holmes,Georg Ramm,Oja Prelovsek,Cordula Hohnen-Behrens,Matthew J. Watt,David E. James,Bruce E. Kemp,Bente Klarlund Pedersen,Mark A. Febbraio +12 more
TL;DR: It is demonstrated that acute IL- 6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK.
Journal ArticleDOI
Role of myokines in exercise and metabolism.
TL;DR: The present review focuses on muscle-derived cytokines, their regulation by exercise, and their possible roles in metabolism and skeletal muscle function and it discusses which cytokines should be classified as true myokines.
Journal ArticleDOI
An overview of mannan structure and mannan-degrading enzyme systems.
TL;DR: The structure of mannans and some biochemical properties and applications of mannan-degrading enzymes are reported, showing a complex system of sulfated structure.