Selection of resistant bacteria at very low antibiotic concentrations.
Erik Gullberg,Sha Cao,Otto G. Berg,Carolina Ilbäck,Linus Sandegren,Diarmaid Hughes,Dan I. Andersson +6 more
TLDR
It is suggested that the low antibiotic concentrations found in many natural environments are important for enrichment and maintenance of resistance in bacterial populations.Abstract:
The widespread use of antibiotics is selecting for a variety of resistance mechanisms that seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected at the high concentrations of antibiotics used therapeutically, but what role the much lower antibiotic concentrations present in many environments plays in selection remains largely unclear. Here we show using highly sensitive competition experiments that selection of resistant bacteria occurs at extremely low antibiotic concentrations. Thus, for three clinically important antibiotics, drug concentrations up to several hundred-fold below the minimal inhibitory concentration of susceptible bacteria could enrich for resistant bacteria, even when present at a very low initial fraction. We also show that de novo mutants can be selected at sub-MIC concentrations of antibiotics, and we provide a mathematical model predicting how rapidly such mutants would take over in a susceptible population. These results add another dimension to the evolution of resistance and suggest that the low antibiotic concentrations found in many natural environments are important for enrichment and maintenance of resistance in bacterial populations.read more
Citations
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Dissertation
Selection for antibiotic resistance in the aquatic environment : novel assays to detect effect concentrations of micropollutants
TL;DR: Thesis overview: Selection and co-selection for antibiotic resistance in a complex community, at low antibiotic concentrations .........................................................................
Journal ArticleDOI
Antibiotics in Austrian drinking water resources, survey 2014: Antibiotika in österreichischen Trinkwasserressourcen, Monitoring 2014
Journal ArticleDOI
Environmental selection and epistasis in an empirical phenotype–environment–fitness landscape
TL;DR: In this paper , the authors quantify all single mutational effects on fitness and phenotype (EC50) of VIM-2 β-lactamase across a 64-fold range of ampicillin concentrations and construct a phenotype-fitness landscape that takes variations in environmental selection pressure into account.
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Antibiotic resistance in soil-plant systems: A review of the source, dissemination, influence factors, and potential exposure risks.
Ruihao Xiao,Danlian Huang,Li Du,Biao Song,Lingshi Yin,Yashi Chen,Lan Gao,Ruijin Li,Hai Huang,Guangming Zeng +9 more
TL;DR: In this article , the prevalence and dissemination of antibiotic resistance in the soil-plant system are highlighted and different underlying mechanisms and detection methods for ARGs transfer between the soil environment and plant compartments are summarized and discussed.
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Effects of Sulfamethoxazole on Growth and Antibiotic Resistance of A Natural Microbial Community
Jasmin Rauseo,Anna Barra Caracciolo,Francesca Spataro,Andrea Visca,Nicoletta Ademollo,Tanita Pescatore,Paola Grenni,Luisa Patrolecco +7 more
TL;DR: The overall results showed that SMX concentrations in the range of those found in the environment did not affect the microbial community growth and did not select for antibiotic-resistant gene (ARG) maintenance or spread and suggests that antibiotic biodegradation needs to be included for fully understanding the resistance phenomena among bacteria.
References
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Antibiotic resistance and its cost: is it possible to reverse resistance?
Dan I. Andersson,Diarmaid Hughes +1 more
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