Selection of resistant bacteria at very low antibiotic concentrations.
Erik Gullberg,Sha Cao,Otto G. Berg,Carolina Ilbäck,Linus Sandegren,Diarmaid Hughes,Dan I. Andersson +6 more
TLDR
It is suggested that the low antibiotic concentrations found in many natural environments are important for enrichment and maintenance of resistance in bacterial populations.Abstract:
The widespread use of antibiotics is selecting for a variety of resistance mechanisms that seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected at the high concentrations of antibiotics used therapeutically, but what role the much lower antibiotic concentrations present in many environments plays in selection remains largely unclear. Here we show using highly sensitive competition experiments that selection of resistant bacteria occurs at extremely low antibiotic concentrations. Thus, for three clinically important antibiotics, drug concentrations up to several hundred-fold below the minimal inhibitory concentration of susceptible bacteria could enrich for resistant bacteria, even when present at a very low initial fraction. We also show that de novo mutants can be selected at sub-MIC concentrations of antibiotics, and we provide a mathematical model predicting how rapidly such mutants would take over in a susceptible population. These results add another dimension to the evolution of resistance and suggest that the low antibiotic concentrations found in many natural environments are important for enrichment and maintenance of resistance in bacterial populations.read more
Citations
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Antibiotic residues in honey in the Chinese market and human health risk assessment
Yuan-Peng Wang,Xiaolian Dong,Minghui Han,Zicheng Yang,Yi Fan Wang,Lu Qian,Min Huang,Baozhang Luo,Hexing Wang,Yu Chen,Qingwu Jiang +10 more
TL;DR: Wang et al. as mentioned in this paper collected 94 honey samples circulating in the Chinese market, determined 20 common antibiotics from four categories in relation to the characteristics of honey samples, and assessed the potential human health risk.
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Metagenomic and HT-qPCR analysis reveal the microbiome and resistome in pig slurry under storage, composting, and anaerobic digestion.
Thi Thuy Do,Stephen Nolan,Nicky Hayes,Vincent O'Flaherty,Catherine M. Burgess,Fiona Brennan,Fiona Walsh +6 more
TL;DR: In this paper , the authors compared the effect of storage, composting, and anaerobic digestion on pig slurry microbiome, resistome and nutrient content, and concluded that composting provides the greatest gain by reducing risk to human health and the environment.
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Bacteriophages in Escherichia coli antimicrobial resistance
Archana Iyer,Elie K. Barbour,Esam I. Azhar,Ishtiaq Qadri,Adeel G. Chaudhary,Adel M. Abuzenadah,Taha A. Kumosani,Ghazi A. Damanhouri,Suhad Bahijri,Ahmed M. Al-Hejin,Afif M. Abdel Nour,Steve Harakeh +11 more
TL;DR: This review aims at compiling information about the different mechanisms by which bacteriophages aid in transferring genes involved in antimicrobial resistance to Escherischia coli in various environments.
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A biochemical engineering view of the quest for immune-potentiating anti-infectives
Wen Kang Chou,Mark P. Brynildsen +1 more
TL;DR: The rationale for pursuing immune-potentiating anti-infectives is summarized, recent efforts that employ engineering approaches to examine phagosomal stressors and their antibacterial activity are reviewed, and how biochemical engineering can contribute further to this exciting field is discussed.
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Antimicrobial resistance in urban river ecosystems.
Sagar Mallikethi Lepakshi Reddy,Kawaljeet Kaur,Pramod Barathe,Varsha Shriram,Muthusamy Govarthanan,Vinay Kumar +5 more
TL;DR: In this paper , a review encompasses the issues of AMR, major drivers and their vital roles in the evolution and spread of ARB with an emphasis on sources and hotspots of diverse ARGs in urban rivers contributing to cooccurrence of ARGs and MGEs.
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