Senescent cells: an emerging target for diseases of ageing.
Bennett G. Childs,Martina Gluscevic,Darren J. Baker,Remi-Martin Laberge,Dan Marquess,Jamie Dananberg,Jan M. van Deursen +6 more
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TLDR
Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.Abstract:
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.read more
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Book ChapterDOI
Senescence as a therapeutic target
TL;DR: In this paper , the authors frame cellular senescence as the protagonist of a complex tissue remodeling process that can be divided into two steps, i.e., activation and clearance of senescent cells.
Book ChapterDOI
Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-Related Diseases.
Posted ContentDOI
Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritis
TL;DR: In this article , various cell subsets from tibial plateau of OA patients are identified, and the mechanism of subchondral microstructure alteration is elaborated using single-cell RNA sequencing technique.
Journal ArticleDOI
Cellular senescence as a driver of cognitive decline triggered by chronic unpredictable stress
TL;DR: In this paper, the authors used the chronic unpredictable stress (CUS) model to mimic stressful life situations and found that, compared with nonstressed control mice, CUS-treated C57BL/6 mice exhibited depressionlike behaviors and cognitive decline.
Journal ArticleDOI
Discovering small-molecule senolytics with deep neural networks
TL;DR: Wong et al. as mentioned in this paper used graph neural networks to predict the senolytic activities of >800,000 molecules and found that three drug-like compounds selectively target senescent cells across different senescence models, with more favorable medicinal chemistry properties than those of ABT-737.
References
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