Senescent cells: an emerging target for diseases of ageing.
Bennett G. Childs,Martina Gluscevic,Darren J. Baker,Remi-Martin Laberge,Dan Marquess,Jamie Dananberg,Jan M. van Deursen +6 more
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TLDR
Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.Abstract:
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.read more
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Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process.
Mariana Toricelli,Arthur Antonio Ruiz Pereira,Guilherme de Souza Abrao,Helena Nascimento Malerba,Julia Maia,Hudson Sousa Buck,Tania Araujo Viel +6 more
TL;DR: This review aims to address the latest information about the different mechanisms related to neuroplasticity and neuronal death and to provide strategies that can improve neuroprotection and decrease the neurodegeneration caused by aging and environmental stressors.
Journal ArticleDOI
Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration
TL;DR: In this article, the role of senescent cells in the maintenance of bone homeostasis during childhood and their contribution to the pathogenesis of chronic musculoskeletal disorders, including osteoporosis, osteoarthritis, and sarcopenia.
Journal ArticleDOI
The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells
Angelica Giuliani,Ilenia Cirilli,Francesco Prattichizzo,Emanuela Mensà,Gianluca Fulgenzi,Jacopo Sabbatinelli,Laura Graciotti,Fabiola Olivieri,Antonio Domenico Procopio,Luca Tiano,Maria Rita Rippo +10 more
TL;DR: It is documented for the first time that some mitomiRs can act as mediators of the multiple but functionally linked biochemical and morphological changes that characterize aging cells and that they can promote different cellular outcomes according to the senescence status of the cell.
Journal ArticleDOI
Recent advances in the field of caloric restriction mimetics and anti-aging molecules.
Jan Martel,Shih Hsin Chang,Cheng Yeu Wu,Hsin Hsin Peng,Tsong Long Hwang,Yun-Fei Ko,John Ding-E Young,David M. Ojcius +7 more
TL;DR: Novel CR mimetics and anti-aging compounds, such as alpha-ketoglutarate, 4,4'-dimethoxychalcone, fungal polysaccharides, inorganic nitrate, and trientine are reviewed, highlighting their possible molecular targets and mechanisms of action.
Journal ArticleDOI
Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice
Christopher T. Cottage,Norman C. Peterson,Jennifer Kearley,Aaron A Berlin,Ximing Xiong,Anna Huntley,Weiguang Zhao,Charles Brown,Annik Migneault,Kamelia Zerrouki,G.J. Criner,Roland Kolbeck,Jane Connor,Raphael Lemaire +13 more
TL;DR: It is suggested that targeting senescence pathways may facilitate alveolar regeneration in chronic obstructive pulmonary diseases by activating cell-proliferation signals through insulin-like growth factor 1.
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