Senescent cells: an emerging target for diseases of ageing.
Bennett G. Childs,Martina Gluscevic,Darren J. Baker,Remi-Martin Laberge,Dan Marquess,Jamie Dananberg,Jan M. van Deursen +6 more
Reads0
Chats0
TLDR
Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.Abstract:
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.read more
Citations
More filters
Journal ArticleDOI
Anthracycline cardiotoxicity: looking for new therapeutic approaches targeting cell senescence?
TL;DR: Two distinct cellular responses to anthracyclines have been identified, cell apoptosis and cell senescence, which both result from DNA damage response activation and may potentially produce different forms of anthrACYcline cardiotoxicity according to the dose or administration regimen.
Journal ArticleDOI
Repair Strategies and Bioactive Functional Materials for Intervertebral Disc
Di Wu,Gaocai Li,Xingyu Zhou,Wei Feng Zhang,Huaizhen Liang,Rongjin Luo,Kun Wang,Xiaobo Feng,Yung-Leem Song,Cao Yang +9 more
TL;DR: In this paper , a review summarizes the advanced progress of bioactive functional materials in intervertebral disc repair and regeneration and discusses their regulatory mechanisms, limitations, challenges as well as their clinical translational prospects in the future.
Journal ArticleDOI
Breathe it in - Spotlight on senescence and regeneration in the lung.
TL;DR: In this paper, the authors discuss lung physiology and pathology as an example of seemingly contradictory role of senescence in structural and functional integrity of the tissue upon damage, and in age-related pulmonary diseases.
Book ChapterDOI
Senolytic Drug Development
TL;DR: The biological significances of cellular senescence in aging are discussed, some of the known naturally occurring and targeted senolytic agents and their targets are summarized, and development of more specific and potent senolytics are urgently needed to improve healthy aging in humans.
Journal ArticleDOI
A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity
Joey H. Li,Yvonne Y. Chen +1 more
TL;DR: In the June issue of Nature, Amor et al. (2020) develop chimeric antigen receptor (CAR)-T cells targeting uPAR, a novel senescent-cell marker, to treat liver adenocarcinoma and liver fibrosis.
References
More filters
Journal ArticleDOI
The serial cultivation of human diploid cell strains.
Leonard Hayflick,P.S. Moorhead +1 more
TL;DR: A consideration of the cause of the eventual degeneration of these strains leads to the hypothesis that non-cumulative external factors are excluded and that the phenomenon is attributable to intrinsic factors which are expressed as senescence at the cellular level.
Journal ArticleDOI
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
Goberdhan P. Dimri,X Lee,G Basile,Meileen Acosta,G Scott,C Roskelley,E E Medrano,Maarten H.K. Linskens,Ivica Rubelj,Olivia M. Pereira-Smith +9 more
TL;DR: It is shown that several human cells express a beta-galactosidase, histochemically detectable at pH 6, upon senescence in culture, which provides in situ evidence that senescent cells may exist and accumulate with age in vivo.
Journal ArticleDOI
The limited in vitro lifetime of human diploid cell strains
TL;DR: The survival curves obtained with human diploid cell strains are comparable to “multiple-hit” or “ multiple-target” curves obtain with other biological systems where an initial threshold dose is required before an exponential form of the curve is established.
Journal ArticleDOI
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.
Reva C. Lawrence,David T. Felson,Charles G. Helmick,Lesley M. Arnold,Hyon K. Choi,Richard A. Deyo,Sherine E. Gabriel,Rosemarie Hirsch,Marc C. Hochberg,Gene G. Hunder,Joanne M. Jordan,Jeffrey N. Katz,Hilal Maradit Kremers,Frederick Wolfe +13 more
TL;DR: This report provides the best available prevalence estimates for the US for osteoarthritis, polymyalgia rheumatica, gout, fibromyalgia, and carpal tunnel syndrome as well as the symptoms of neck and back pain.
Related Papers (5)
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more