Senescent cells: an emerging target for diseases of ageing.
Bennett G. Childs,Martina Gluscevic,Darren J. Baker,Remi-Martin Laberge,Dan Marquess,Jamie Dananberg,Jan M. van Deursen +6 more
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TLDR
Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.Abstract:
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.read more
Citations
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Selective photodynamic eradication of senescent cells with a β-galactosidase-activated photosensitiser.
TL;DR: In this article , a β-galactosidase-responsive photosensitiser was designed and synthesized, which contains a galactosyl substrate, a boron dipyrromethene-based photoensitising unit and a black hole quencher 2 connected via an AB2-type self-immolative linker.
Journal ArticleDOI
Senescence and Inflammation: Summary of a Gerontological Society of America and National Institute on Aging-Sponsored Symposium.
Xu Zhang,Daniel J Tyrrell,Tamara Alliston,Birgit Schilling,Matthew J. Yousefzadeh,Marissa J. Schafer +5 more
TL;DR: The National Institute on Aging (NIA) sponsored a symposium at the Gerontological Society of America (GSA) annual meeting in Indianapolis, Indiana to discuss recent discoveries related to senescent and inflammatory mechanisms in aging and disease as mentioned in this paper .
Journal ArticleDOI
Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond
TL;DR: Natural killer (NK) cells are a type of innate immune cells that represent a unique biology in cancer immune surveillance and can serve as a source for genetically engineered immune cell therapies as discussed by the authors .
Journal ArticleDOI
Latest insights in disease-modifying osteoarthritis drugs development
TL;DR: In this paper , the efficacy and safety profiles of various disease modifying osteoarthritis drugs targeting cartilage, synovitis, and subchondral bone endotypes in phase 2 and 3 clinical trials are summarized.
Journal ArticleDOI
Localization of senescent cells under cavity preparations in rats and restoration of reparative dentin formation by senolytics.
Haitao Liu,Ya'nan Gong,Masato Nakagawa,Hiroaki Tanimoto,Kazushi Yoshikawa,Yoshitomo Honda,Kazuyo Yamamoto +6 more
TL;DR: In this article , the authors established a rat model of dental cavity preparation and analyzed the spatiotemporal localization of senescent cells in the pulp and found that p21 and p16-positive cells appeared mostly around the pulp horn under DCP.
References
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