Senescent cells: an emerging target for diseases of ageing.
Bennett G. Childs,Martina Gluscevic,Darren J. Baker,Remi-Martin Laberge,Dan Marquess,Jamie Dananberg,Jan M. van Deursen +6 more
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TLDR
Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.Abstract:
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.read more
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Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.
Liangliang Liu,Chang Zhao,Haiyan Zhang,Yuheng Lu,Bingsheng Luo,Zihao Yao,Yan Shao,Hua Zeng,Chun Zeng,Rongkai Zhang,Hang Fang,Jianying Pan,Xiaochun Bai,Daozhang Cai +13 more
TL;DR: In this paper, the role and mechanism of asporin in modulating chondrocyte senescence in osteoarthritis (OA) pathology was investigated in mice.
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The emerging role of cellular senescence in complications of COVID-19.
Mohiuddin,Kazuo Kasahara +1 more
TL;DR: In this paper, the impact of cellular senescence on COVID-19 complications was investigated and potential therapeutic targets for eliminating senescent cells during the CoVirus disease 2019 pandemic were explored.
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Retrotransposons as a Source of DNA Damage in Neurodegeneration
Eugenie Peze-Heidsieck,Tom Bonnifet,R. Znaidi,Camille Ravel-Godreuil,Olivia Massiani-Beaudoin,Rajiv L. Joshi,Julia Fuchs +6 more
TL;DR: The potential contribution of LINE-1 elements in inducing DNA damage and genomic instability, which are emerging pathological features in NDs, are discussed.
Journal ArticleDOI
Cellular senescence and acute kidney injury
TL;DR: In this paper , a review integrates the existing studies on senescence in AKI from several aspects to find meaningful research directions to improve the prognosis of AKI and prevent the progression of CKD.
Journal ArticleDOI
Pulsed electromagnetic fields attenuate glucocorticoid-induced bone loss by targeting senescent LepR+ bone marrow mesenchymal stromal cells
TL;DR: In4a with LepR in longitudinal femoral sections as mentioned in this paper showed that PEMFs alleviate bone loss induced by glucocorticoids by eliminating senescent cells, maintaining angiogenesis-osteogenesis coupling, and shedding light on the mechanisms.
References
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