Senescent cells: an emerging target for diseases of ageing.
Bennett G. Childs,Martina Gluscevic,Darren J. Baker,Remi-Martin Laberge,Dan Marquess,Jamie Dananberg,Jan M. van Deursen +6 more
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TLDR
Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.Abstract:
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.read more
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A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan
Quentin Alle,Enora Le Borgne,Paul Bensadoun,Camille Lemey,Nelly Béchir,Mélissa Gabanou,Fanny E. Estermann,Christelle Bertrand-Gaday,Laurence Pessemesse,Karine Toupet,Romain Desprat,Jérôme Vialaret,Christophe Hirtz,Danièle Noël,Christian Jorgensen,François Casas,Ollivier Milhavet,Jean-Marc Lemaitre +17 more
TL;DR: It is shown that a single short reprogramming induction is sufficient to prevent musculoskeletal functions deterioration of mice, when applied in early life and in old age, treated mice have improved tissue structures in kidney, spleen, skin, and lung.
Journal ArticleDOI
Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control.
Maria Cavinato,Corina T. Madreiter-Sokolowski,Corina T. Madreiter-Sokolowski,Sabrina Büttner,Sabrina Büttner,Markus Schosserer,Markus Schosserer,Werner Zwerschke,Sophia Wedel,Johannes Grillari,Johannes Grillari,Johannes Grillari,Wolfgang F. Graier,Pidder Jansen-Dürr +13 more
TL;DR: Mechanisms of senescence that are related to mitochondria and their interorganelle communication, and the involvement of proteostasis networks and metabolic control in the senescent phenotype are reviewed.
Journal ArticleDOI
Cellular senescence in the tumor microenvironment and context-specific cancer treatment strategies.
TL;DR: In this paper, a review summarizes the molecular mechanisms regarding cellular senescence, focusing on the dual roles played by senescences, and offers some direction toward successful treatments targeting harmful senescent cells.
Journal ArticleDOI
A rapid-response near-infrared fluorescent probe with a large Stokes shift for senescence-associated β-galactosidase activity detection and imaging of senescent cells
Wenjing Qiu,Xiaokang Li,Donglei Shi,Xinming Li,Ying Gao,Jinwen Li,Fei Mao,Yuan Guo,Jian Li,Jian Li +9 more
TL;DR: It is demonstrated that KSL0401 is a potential detection tool in the imaging research of aging by enabling to detect the endogenous SA-β-gal activity in living cells, and distinguish between senescent cells and non-senescent Cells and qualify the degree of aging.
Posted ContentDOI
KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype
Boyi Zhang,Qilai Long,Shanshan Wu,Shuling Song,Qixia Xu,Liu Han,Min Qian,Xiaohui Ren,Jing Jiang,Qiang Fu,Jianming Guo,Xiaoling Zhang,Xing Chang,Eric Lam,Judith Campisi,Judith Campisi,James L. Kirkland,Yu Sun,Yu Sun,Yu Sun +19 more
TL;DR: This study supports the dynamic change of H3K9/H3K36 methylation marks during cellular senescence, identifies an unusually permissive chromatin state, unmasks KDM4 as a key modulator of the SASP, and presents a novel therapeutic avenue to manipulate cellular senencence and curtail age-related pathologies.
References
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