Journal ArticleDOI
Solvent-free melt electrospinning for preparation of fast dissolving drug delivery system and comparison with solvent-based electrospun and melt extruded systems.
Zsombor Kristóf Nagy,Attlia Balogh,Gábor Drávavölgyi,James W. Ferguson,Hajnalka Pataki,Balázs Vajna,György Marosi +6 more
Reads0
Chats0
TLDR
The results demonstrate that solvent-free MES is a promising, novel technique for the production of drug delivery systems with enhanced dissolution because it can combine the advantages of EX and solvent-based electrospinning and huge product surface area.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 2013-02-01. It has received 119 citations till now. The article focuses on the topics: Melt electrospinning & Electrospinning.read more
Citations
More filters
Journal ArticleDOI
Melt electrospinning today: An opportune time for an emerging polymer process
Toby D. Brown,Paul D. Dalton,Paul D. Dalton,Dietmar W. Hutmacher,Dietmar W. Hutmacher,Dietmar W. Hutmacher +5 more
TL;DR: In this article, the authors review the significant advancements in theoretic modeling of the underlying physical principles, coupled with experimental validation using a variety of technical devices and designs that allow well-controlled fiber formation using optimized material and operating parameters.
Journal ArticleDOI
Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review
Levente L. Simon,Hajnalka Pataki,György Marosi,Fabian Meemken,Konrad Hungerbühler,Alfons Baiker,Srinivas Tummala,Brian Glennon,Martin Kuentz,Gerry Steele,Herman J. M. Kramer,James W. Rydzak,Zeng-Ping Chen,Julian Morris,Francois Kjell,Ravendra Singh,Rafiqul Gani,Krist V. Gernaey,Marjatta Louhi-Kultanen,John Oreilly,Niklas Sandler,Osmo Antikainen,Jouko Yliruusi,Patrick Frohberg,Joachim Ulrich,Richard D. Braatz,Tom Leyssens,Moritz von Stosch,Rui Oliveira,Reginald B. H. Tan,Huiquan Wu,Mansoor A. Khan,Des O'grady,Anjan Pandey,Remko Westra,Emmanuel Delle-Case,Detlef Pape,Daniele Angelosante,Yannick Maret,Olivier Steiger,Miklos Lenner,Kaoutar Abbou-Oucherif,Zoltan K. Nagy,James D. Litster,Vamsi Krishna Kamaraju,Min-Sen Chiu +45 more
TL;DR: In this paper, a multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and control methods) and presenting applications both in industrial laboratories and in manufacture.
Journal ArticleDOI
Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review.
TL;DR: The development, advantages and pharmaceutical applications of electrospinning for producing polymeric amorphous solid dispersions (ASDs) are addressed.
Journal ArticleDOI
Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review.
Luis Padrela,Miguel Rodrigues,Andreia Duarte,Ana M.A. Dias,Mara E.M. Braga,Hermínio C. de Sousa +5 more
TL;DR: A comprehensive state‐of‐the‐art review on scCO2‐based processes focused on the formation and on the control of the physicochemical, structural and morphological properties of amorphous/crystalline pure drug nanoparticles.
Journal ArticleDOI
Near-Field Electrospinning: Progress and Applications
He Xiaoxiao,Jie Zheng,Gui-Feng Yu,Ming-Hao You,Miao Yu,Miao Yu,Xin Ning,Yun-Ze Long,Yun-Ze Long +8 more
TL;DR: In order to improve the controllable deposition of electrospun fibers, near-field electrospinning (NFES) has been proposed and developed in recent years as mentioned in this paper.
References
More filters
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
Drug-like properties and the causes of poor solubility and poor permeability
TL;DR: There are currently about 10000 drug-like compounds, and true diversity does not exist in experimental combinatorial chemistry screening libraries because current ADME experimental screens are multi-mechanisms, and predictions get worse as more data accumulates.
Journal ArticleDOI
Wound healing dressings and drug delivery systems: a review.
TL;DR: The requirement for formulations with improved properties for effective and accurate delivery of the required therapeutic agents and general formulation approaches towards achieving optimum physical properties and controlled delivery characteristics for an active wound healing dosage form are considered.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.
Journal ArticleDOI
Injectable matrices and scaffolds for drug delivery in tissue engineering
TL;DR: This review aims to outline injectable materials and processing techniques used in both tissue engineering and drug delivery and to describe methods by which current injectable material in the field of drug delivery can be adapted for use as injectable scaffolds for tissue engineering.