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Statistical methods
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The article was published on 1967-01-01 and is currently open access. It has received 22994 citations till now.read more
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Journal ArticleDOI
Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions.
TL;DR: Data clearly show that after 48 h of marked hyperglycemia, glucose influence upon insulin secretion in the rat is severely impaired, and this model provides a relatively easy and reproducible method to study the effects of long-term hyper glycemia on B cell function.
Journal ArticleDOI
Comparison of five antihypertensive monotherapies and placebo for change in left ventricular mass in patients receiving nutritional-hygienic therapy in the Treatment of Mild Hypertension Study (TOMHS).
Philip R. Liebson,Greg Grandits,Sinda Dianzumba,Ronald J. Prineas,Richard H. Grimm,James D. Neaton,Jeremiah Stamler +6 more
TL;DR: NH intervention with emphasis on weight loss and reduction of dietary sodium is as effective as NH intervention plus pharmacological treatment in reducing echocardiographically determined LVM, despite a smaller decrease in blood pressure in the NH intervention only group.
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Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus
TL;DR: In nonketotic diabetics total splanchnic output of glucose is comparable to controls, but the relative contribution of gluconeogenesis may be increased by more than 50%, and the failure of glucose infusion to inhibit hepatic glucose output suggests that the exquisite sensitivity of the liver to the infusion of glucose in normal man is a consequence of glucose-induced insulin secretion.
Journal ArticleDOI
Uraemic bleeding: role of anaemia and beneficial effect of red cell transfusions
TL;DR: Bleeding time, altered in most uraemic patients, may be influenced by packed cell volume (PCV), and the platelet-mediated haemorrhagic tendency in uraemia may be successfully managed by raising PCV values to above 30%.
Journal ArticleDOI
Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: the Systolic Hypertension in the Elderly Program (SHEP).
Perry Hm,Barry R. Davis,Thomas R. Price,William B. Applegate,Fields Ws,Jack M. Guralnik,Lewis H. Kuller,Sarah Pressel,Jeremiah Stamler,Jeffrey L. Probstfield +9 more
TL;DR: Antihypertensive drug treatment reduced the incidence of both hemorrhagic and ischemic strokes in older patients, and reduction in stroke incidence occurred when specific systolic blood pressure goals were attained.