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Statistical methods
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The article was published on 1967-01-01 and is currently open access. It has received 22994 citations till now.read more
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Journal ArticleDOI
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.
Joseph F. Costello,Joseph F. Costello,Michael C. Frühwald,Michael C. Frühwald,Dominic J. Smiraglia,Laura J. Rush,Gavin P. Robertson,Xin Gao,Fred A. Wright,Jamison D. Feramisco,Päivi Peltomäki,James C. Lang,David E. Schuller,Li Yu,Clara D. Bloomfield,Michael A. Caligiuri,Allan J. Yates,Ryo Nishikawa,H.-J. Su Huang,Nicholas J. Petrelli,Xueli Zhang,M. S. O'Dorisio,William A. Held,Webster K. Cavenee,Webster K. Cavenee,Christoph Plass +25 more
TL;DR: This report reports a global analysis of the methylation status of 1,184 unselected CpG islands in each of 98 primary human tumours using restriction landmark genomic scanning (RLGS), and estimates that an average of 600 C pG islands were aberrantly methylated in the tumours, including early stage tumours.
Journal ArticleDOI
Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.
TL;DR: The utility of quick- freezing as a technique to capture biological processes as evanescent as synaptic transmission as well as physiological demonstrations that quanta are discharged independently has been established.
Journal ArticleDOI
Validation of tetrapolar bioelectrical impedance method to assess human body composition.
TL;DR: The validity and reliability of the tetrapolar impedance method for use in assessment of body composition in healthy humans is established, with a lower predictive error or standard error of the estimates of estimating body fatness than did a standard anthropometric technique.
Journal ArticleDOI
Expressed Emotion and Psychiatric Relapse: A Meta-analysis
TL;DR: A meta-analysis of all available EE and outcome studies in schizophrenia confirmed that EE is a significant and robust predictor of relapse in schizophrenia and demonstrated that the EE-relapse relationship was strongest for patients with more chronic schizophrenic illness.
Journal ArticleDOI
Increased incidence of non-insulin-dependent diabetes mellitus among adolescents.
Orit Pinhas-Hamiel,Lawrence M. Dolan,Stephen R. Daniels,Debra Standiford,Philip R. Khoury,Philip Zeitler +5 more
TL;DR: There is an increasing incidence of non-insulin- dependent diabetes mellitus among adolescents in Greater Cincinnati, accompanying the national rise in adolescent obesity.