Targeting CDK4/6 in patients with cancer
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TLDR
Current preclinical and clinical data for three selective CDK4/6 inhibitors have been described and the combination of these novel agents with endocrine therapy, such as palbociclib's recent first-line approval in combination with letrozole, is expected to transform the treatment of HR+ breast cancer.About:
This article is published in Cancer Treatment Reviews.The article was published on 2016-04-01 and is currently open access. It has received 316 citations till now. The article focuses on the topics: Palbociclib & Cancer.read more
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Journal ArticleDOI
Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer
Gabriel N. Hortobagyi,Salomon M. Stemmer,Howard A. Burris,Yoon Sim Yap,Gabe S. Sonke,Shani Paluch-Shimon,Mario Campone,Kimberly L. Blackwell,Fabrice Andre,Eric P. Winer,Wolfgang Janni,Sunil Verma,Pierfranco Conte,Carlos L. Arteaga,David Cameron,Katarína Petráková,Lowell L. Hart,Cristian Villanueva,A. Chan,Erik Jakobsen,Arnd Nusch,Olga Burdaeva,Eva-Maria Grischke,Emilio Alba,Erik Wist,Norbert Marschner,Anne Favret,Denise A. Yardley,Thomas Bachelot,Ling-Ming Tseng,Sibel Blau,Fengjuan Xuan,Farida Souami,Michelle Miller,C. Germa,Samit Hirawat,Joyce O'Shaughnessy +36 more
TL;DR: Among patients receiving initial systemic treatment for HR-positive, HER2-negative advanced breast cancer, the duration of progression-free survival was significantly longer among those receiving ribociclib plus letrozole than among those received placebo plus let rozole, with a higher rate of myelosuppression in the ribocIClib group.
Journal ArticleDOI
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Christopher J. Ricketts,Aguirre A. de Cubas,Huihui Fan,Christof C. Smith,Martin Lang,Ed Reznik,Reanne Bowlby,Ewan A. Gibb,Rehan Akbani,Rameen Beroukhim,Donald P. Bottaro,Toni K. Choueiri,Richard A. Gibbs,Andrew K. Godwin,Scott M. Haake,A. Ari Hakimi,Elizabeth P. Henske,James J. Hsieh,Thai H. Ho,Rupa S. Kanchi,Bhavani Krishnan,David J. Kwiatkowski,Wembin Lui,Maria Merino,Gordon B. Mills,Jerome Myers,Michael L. Nickerson,Victor E. Reuter,Laura S. Schmidt,C Simon Shelley,Hui Shen,Brian Shuch,Sabina Signoretti,Ramaprasad Srinivasan,Pheroze Tamboli,George Thomas,Benjamin G. Vincent,Cathy D. Vocke,David A. Wheeler,Lixing Yang,William Y. Kim,A. Gordon Robertson,Paul T. Spellman,W. Kimryn Rathmell,W. Marston Linehan +44 more
TL;DR: Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers.
Journal ArticleDOI
Genome-Informed Targeted Therapy for Osteosarcoma
Leanne C. Sayles,Marcus R. Breese,Amanda Koehne,Stanley G. Leung,Alex G. Lee,Heng-Yi Liu,Aviv Spillinger,Avanthi Tayi Shah,Bogdan Tanasa,Krystal Straessler,Florette K. Hazard,Sheri L. Spunt,Neyssa Marina,Grace E. Kim,Soo-Jin Cho,Raffi S. Avedian,David G. Mohler,Mi-Ok Kim,Steven G. DuBois,Douglas S. Hawkins,E. Alejandro Sweet-Cordero +20 more
TL;DR: Using patient-derived tumor xenografts, it is demonstrated that targeting of patient-specific SCNAs leads to significant decrease in tumor burden, providing a road map for genome-informed treatment of osteosarcoma.
Journal ArticleDOI
Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review
Kamal Pandey,Hee-Jung An,Seung-Ki Kim,Seung Ah Lee,Sewha Kim,Sun Min Lim,Gun Min Kim,Joohyuk Sohn,Yong Wha Moon +8 more
TL;DR: This review summarizes the currently available knowledge regarding mechanisms of resistance to CDK4/6 inhibitors, and possible therapeutic strategies that may overcome this resistance as well.
Journal ArticleDOI
Exploiting senescence for the treatment of cancer
TL;DR: In this article , the authors discuss how senescence can be induced in cancer cells and how distinctive features of senescent cancer cells might be exploited for their selective eradication as a potential cancer therapy.
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The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study
Richard S. Finn,John Crown,István Láng,Katalin Boér,Igor Bondarenko,Sergey O. Kulyk,Johannes Ettl,Ravindranath Patel,Tamás Pintér,Marcus Schmidt,Yaroslav Shparyk,Anu Thummala,Nataliya L. Voytko,Camilla Fowst,Xin Huang,Sindy T. Kim,Sophia Randolph,Dennis J. Slamon +17 more
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Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer
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